Variant position: 24 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SPADKTNVKAAWGKVGAHAG EYGAEALERMFLSFPTTKTYF
Gorilla SPADKTNVKAAWGKVGAHAG DYGAEALERMFLSFPTTKTYF
Rhesus macaque SPADKSNVKAAWGKVGGHAG EYGAEALERMFLSFPTTKTYF
Chimpanzee SPADKTNVKAAWGKVGAHAG EYGAEALERMFLSFPTTKTYF
Mouse SGEDKSNIKAAWGKIGGHGA EYGAEALERMFASFPTTKTYF
Rat SADDKTNIKNCWGKIGGHGG EYGEEALQRMFAAFPTTKTYF
Pig SAADKANVKAAWGKVGGQAG AHGAEALERMFLGFPTTKTYF
Bovine SAADKGNVKAAWGKVGGHAA EYGAEALERMFLSFPTTKTYF
Rabbit SPADKTNIKTAWEKIGSHGG EYGAEAVERMFLGFPTTKTYF
Sheep SAADKSNVKAAWGKVGGNAG AYGAEALERMFLSFPTTKTYF
Cat SAADKSNVKACWGKIGSHAG EYGAEALERTFCSFPTTKTYF
Horse SAADKTNVKAAWSKVGGHAG EYGAEALERMFLGFPTTKTYF
Chicken SAADKNNVKGIFTKIAGHAE EYGAETLERMFTTYPPTKTYF
Xenopus tropicalis TADDKKHIKAIWPSVAAHGD KYGGEALHRMFMCAPKTKTYF
Zebrafish SDTDKAVVKAIWAKISPKAD EIGAEALARMLTVYPQTKTYF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
41 – 41 N-linked (Glc) (glycation) lysine; alternate
22 – 36
Hb Reims [alpha 2(23)(B4)Glu----Gly beta 2]: a new alpha chain variant with slightly decreased stability.
Bardakdjian-Michau J.; Rosa J.; Galacteros F.; Lancelot M.; Marquart F.X.;
Cited for: VARIANT REIMS GLY-24;
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