Variant position: 25 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PADKTNVKAAWGKVGAHAGE YGAEALERMFLSFPTTKTYFP
Gorilla PADKTNVKAAWGKVGAHAGD YGAEALERMFLSFPTTKTYFP
Rhesus macaque PADKSNVKAAWGKVGGHAGE YGAEALERMFLSFPTTKTYFP
Chimpanzee PADKTNVKAAWGKVGAHAGE YGAEALERMFLSFPTTKTYFP
Mouse GEDKSNIKAAWGKIGGHGAE YGAEALERMFASFPTTKTYFP
Rat ADDKTNIKNCWGKIGGHGGE YGEEALQRMFAAFPTTKTYFS
Pig AADKANVKAAWGKVGGQAGA HGAEALERMFLGFPTTKTYFP
Bovine AADKGNVKAAWGKVGGHAAE YGAEALERMFLSFPTTKTYFP
Rabbit PADKTNIKTAWEKIGSHGGE YGAEAVERMFLGFPTTKTYFP
Sheep AADKSNVKAAWGKVGGNAGA YGAEALERMFLSFPTTKTYFP
Cat AADKSNVKACWGKIGSHAGE YGAEALERTFCSFPTTKTYFP
Horse AADKTNVKAAWSKVGGHAGE YGAEALERMFLGFPTTKTYFP
Chicken AADKNNVKGIFTKIAGHAEE YGAETLERMFTTYPPTKTYFP
Xenopus tropicalis ADDKKHIKAIWPSVAAHGDK YGGEALHRMFMCAPKTKTYFP
Zebrafish DTDKAVVKAIWAKISPKADE IGAEALARMLTVYPQTKTYFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
25 – 26 (Microbial infection) Cleavage; by N.americanus apr-2
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
41 – 41 N-linked (Glc) (glycation) lysine; alternate
22 – 36
Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant.
Groff P.; Galacteros F.; Kalmes G.; Blouquit Y.; Wajcman H.;
Cited for: VARIANT LUXEMBOURG HIS-25;
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