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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.Tyr25His

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 25 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Tyrosine (Y) to Histidine (H) at position 25 (Y25H, p.Tyr25His). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and aromatic (Y) to medium size and polar (H) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In Luxembourg; unstable. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 25 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help PADKTNVKAAWGKVGAHAGE Y GAEALERMFLSFPTTKTYFP The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         PADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFP

Gorilla                       PADKTNVKAAWGKVGAHAGDYGAEALERMFLSFPTTKTYFP

                              PADKTNIKSTWDKIGGHAGDYGGEALDRTFQSFPTTKTYFP

Rhesus macaque                PADKSNVKAAWGKVGGHAGEYGAEALERMFLSFPTTKTYFP

Chimpanzee                    PADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFP

Mouse                         GEDKSNIKAAWGKIGGHGAEYGAEALERMFASFPTTKTYFP

Rat                           ADDKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYFS

Pig                           AADKANVKAAWGKVGGQAGAHGAEALERMFLGFPTTKTYFP

Bovine                        AADKGNVKAAWGKVGGHAAEYGAEALERMFLSFPTTKTYFP

Rabbit                        PADKTNIKTAWEKIGSHGGEYGAEAVERMFLGFPTTKTYFP

Sheep                         AADKSNVKAAWGKVGGNAGAYGAEALERMFLSFPTTKTYFP

Cat                           AADKSNVKACWGKIGSHAGEYGAEALERTFCSFPTTKTYFP

Horse                         AADKTNVKAAWSKVGGHAGEYGAEALERMFLGFPTTKTYFP

Chicken                       AADKNNVKGIFTKIAGHAEEYGAETLERMFTTYPPTKTYFP

Xenopus tropicalis            ADDKKHIKAIWPSVAAHGDKYGGEALHRMFMCAPKTKTYFP

Zebrafish                     DTDKAVVKAIWAKISPKADEIGAEALARMLTVYPQTKTYFS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Site 12 – 12 Not glycated
Site 25 – 26 (Microbial infection) Cleavage; by N.americanus apr-2
Modified residue 8 – 8 N6-succinyllysine; alternate
Modified residue 9 – 9 Phosphothreonine
Modified residue 12 – 12 N6-succinyllysine
Modified residue 17 – 17 N6-acetyllysine; alternate
Modified residue 17 – 17 N6-succinyllysine; alternate
Modified residue 25 – 25 Phosphotyrosine
Modified residue 36 – 36 Phosphoserine
Modified residue 41 – 41 N6-succinyllysine; alternate
Glycosylation 8 – 8 N-linked (Glc) (glycation) lysine; alternate
Glycosylation 17 – 17 N-linked (Glc) (glycation) lysine; alternate
Glycosylation 41 – 41 N-linked (Glc) (glycation) lysine; alternate
Helix 22 – 36



Literature citations
Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant.
Groff P.; Galacteros F.; Kalmes G.; Blouquit Y.; Wajcman H.;
Hemoglobin 13:429-436(1989)
Cited for: VARIANT LUXEMBOURG HIS-25;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.