Sequence information
Variant position: 25 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
PADKTNVKAAWGKVGAHAGE
Y GAEALERMFLSFPTTKTYFP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PADKTNVKAAWGKVGAHAGEY GAEALERMFLSFPTTKTYFP
Gorilla PADKTNVKAAWGKVGAHAGDY GAEALERMFLSFPTTKTYFP
PADKTNIKSTWDKIGGHAGDY GGEALDRTFQSFPTTKTYFP
Rhesus macaque PADKSNVKAAWGKVGGHAGEY GAEALERMFLSFPTTKTYFP
Chimpanzee PADKTNVKAAWGKVGAHAGEY GAEALERMFLSFPTTKTYFP
Mouse GEDKSNIKAAWGKIGGHGAEY GAEALERMFASFPTTKTYFP
Rat ADDKTNIKNCWGKIGGHGGEY GEEALQRMFAAFPTTKTYFS
Pig AADKANVKAAWGKVGGQAGAH GAEALERMFLGFPTTKTYFP
Bovine AADKGNVKAAWGKVGGHAAEY GAEALERMFLSFPTTKTYFP
Rabbit PADKTNIKTAWEKIGSHGGEY GAEAVERMFLGFPTTKTYFP
Sheep AADKSNVKAAWGKVGGNAGAY GAEALERMFLSFPTTKTYFP
Cat AADKSNVKACWGKIGSHAGEY GAEALERTFCSFPTTKTYFP
Horse AADKTNVKAAWSKVGGHAGEY GAEALERMFLGFPTTKTYFP
Chicken AADKNNVKGIFTKIAGHAEEY GAETLERMFTTYPPTKTYFP
Xenopus tropicalis ADDKKHIKAIWPSVAAHGDKY GGEALHRMFMCAPKTKTYFP
Zebrafish DTDKAVVKAIWAKISPKADEI GAEALARMLTVYPQTKTYFS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Site
12 – 12
Not glycated
Site
25 – 26
(Microbial infection) Cleavage; by N.americanus apr-2
Modified residue
8 – 8
N6-succinyllysine; alternate
Modified residue
9 – 9
Phosphothreonine
Modified residue
12 – 12
N6-succinyllysine
Modified residue
17 – 17
N6-acetyllysine; alternate
Modified residue
17 – 17
N6-succinyllysine; alternate
Modified residue
25 – 25
Phosphotyrosine
Modified residue
36 – 36
Phosphoserine
Modified residue
41 – 41
N6-succinyllysine; alternate
Glycosylation
8 – 8
N-linked (Glc) (glycation) lysine; alternate
Glycosylation
17 – 17
N-linked (Glc) (glycation) lysine; alternate
Glycosylation
41 – 41
N-linked (Glc) (glycation) lysine; alternate
Helix
22 – 36
Literature citations
Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant.
Groff P.; Galacteros F.; Kalmes G.; Blouquit Y.; Wajcman H.;
Hemoglobin 13:429-436(1989)
Cited for: VARIANT LUXEMBOURG HIS-25;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.