Variant position: 27 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DKTNVKAAWGKVGAHAGEYG AEALERMFLSFPTTKTYFPHF-
Gorilla DKTNVKAAWGKVGAHAGDYG AEALERMFLSFPTTKTYFPHF
Rhesus macaque DKSNVKAAWGKVGGHAGEYG AEALERMFLSFPTTKTYFPHF
Chimpanzee DKTNVKAAWGKVGAHAGEYG AEALERMFLSFPTTKTYFPHF
Mouse DKSNIKAAWGKIGGHGAEYG AEALERMFASFPTTKTYFPHF
Rat DKTNIKNCWGKIGGHGGEYG EEALQRMFAAFPTTKTYFSHI
Pig DKANVKAAWGKVGGQAGAHG AEALERMFLGFPTTKTYFPHF
Bovine DKGNVKAAWGKVGGHAAEYG AEALERMFLSFPTTKTYFPHF
Rabbit DKTNIKTAWEKIGSHGGEYG AEAVERMFLGFPTTKTYFPHF
Sheep DKSNVKAAWGKVGGNAGAYG AEALERMFLSFPTTKTYFPHF
Cat DKSNVKACWGKIGSHAGEYG AEALERTFCSFPTTKTYFPHF
Horse DKTNVKAAWSKVGGHAGEYG AEALERMFLGFPTTKTYFPHF
Chicken DKNNVKGIFTKIAGHAEEYG AETLERMFTTYPPTKTYFPHF
Xenopus tropicalis DKKHIKAIWPSVAAHGDKYG GEALHRMFMCAPKTKTYFPDF
Zebrafish DKAVVKAIWAKISPKADEIG AEALARMLTVYPQTKTYFSHW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
41 – 41 N-linked (Glc) (glycation) lysine; alternate
22 – 36
Hb Shenyang (alpha 26 (B7) Ala replaced by Glu): a new unstable variant found in China.
Zeng Y.-T.; Huang S.-Z.; Zhou X.; Qiu X.-K.; Dong Q.; Li M.; Bai J.;
Cited for: VARIANT SHENYANG GLU-27;
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