Variant position: 28 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KTNVKAAWGKVGAHAGEYGA EALERMFLSFPTTKTYFPHF-D
Gorilla KTNVKAAWGKVGAHAGDYGA EALERMFLSFPTTKTYFPHF-
Rhesus macaque KSNVKAAWGKVGGHAGEYGA EALERMFLSFPTTKTYFPHF-
Chimpanzee KTNVKAAWGKVGAHAGEYGA EALERMFLSFPTTKTYFPHF-
Mouse KSNIKAAWGKIGGHGAEYGA EALERMFASFPTTKTYFPHF-
Rat KTNIKNCWGKIGGHGGEYGE EALQRMFAAFPTTKTYFSHI-
Pig KANVKAAWGKVGGQAGAHGA EALERMFLGFPTTKTYFPHF-
Bovine KGNVKAAWGKVGGHAAEYGA EALERMFLSFPTTKTYFPHF-
Rabbit KTNIKTAWEKIGSHGGEYGA EAVERMFLGFPTTKTYFPHF-
Sheep KSNVKAAWGKVGGNAGAYGA EALERMFLSFPTTKTYFPHF-
Cat KSNVKACWGKIGSHAGEYGA EALERTFCSFPTTKTYFPHF-
Horse KTNVKAAWSKVGGHAGEYGA EALERMFLGFPTTKTYFPHF-
Chicken KNNVKGIFTKIAGHAEEYGA ETLERMFTTYPPTKTYFPHF-
Xenopus tropicalis KKHIKAIWPSVAAHGDKYGG EALHRMFMCAPKTKTYFPDF-
Zebrafish KAVVKAIWAKISPKADEIGA EALARMLTVYPQTKTYFSHWA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
41 – 41 N-linked (Glc) (glycation) lysine; alternate
22 – 36
Locus assignment of two alpha-globin structural mutants from the Caribbean basin: alpha Fort de France (alpha 45 Arg) and alpha Spanish Town (alpha 27 Val).
Cash F.E.; Monplaisir N.; Goossens M.; Liebhaber S.A.;
Cited for: VARIANTS SPANISH TOWN VAL-28 AND FORT DE FRANCE ARG-46;
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