Sequence information
Variant position: 32 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
KAAWGKVGAHAGEYGAEALE
R MFLSFPTTKTYFPHFDLSHG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KAAWGKVGAHAGEYGAEALER MFLSFPTTKTYFPHF-DLSHG
Gorilla KAAWGKVGAHAGDYGAEALER MFLSFPTTKTYFPHF-DLSH
KSTWDKIGGHAGDYGGEALDR TFQSFPTTKTYFPHF-DLSP
Rhesus macaque KAAWGKVGGHAGEYGAEALER MFLSFPTTKTYFPHF-DLSH
Chimpanzee KAAWGKVGAHAGEYGAEALER MFLSFPTTKTYFPHF-DLSH
Mouse KAAWGKIGGHGAEYGAEALER MFASFPTTKTYFPHF-DVSH
Rat KNCWGKIGGHGGEYGEEALQR MFAAFPTTKTYFSHI-DVSP
Pig KAAWGKVGGQAGAHGAEALER MFLGFPTTKTYFPHF-NLSH
Bovine KAAWGKVGGHAAEYGAEALER MFLSFPTTKTYFPHF-DLSH
Rabbit KTAWEKIGSHGGEYGAEAVER MFLGFPTTKTYFPHF-DFTH
Sheep KAAWGKVGGNAGAYGAEALER MFLSFPTTKTYFPHF-DLSH
Cat KACWGKIGSHAGEYGAEALER TFCSFPTTKTYFPHF-DLSH
Horse KAAWSKVGGHAGEYGAEALER MFLGFPTTKTYFPHF-DLSH
Chicken KGIFTKIAGHAEEYGAETLER MFTTYPPTKTYFPHF-DLSH
Xenopus tropicalis KAIWPSVAAHGDKYGGEALHR MFMCAPKTKTYFPDF-DFSE
Zebrafish KAIWAKISPKADEIGAEALAR MLTVYPQTKTYFSHWADLSP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Site
12 – 12
Not glycated
Modified residue
12 – 12
N6-succinyllysine
Modified residue
17 – 17
N6-acetyllysine; alternate
Modified residue
17 – 17
N6-succinyllysine; alternate
Modified residue
25 – 25
Phosphotyrosine
Modified residue
36 – 36
Phosphoserine
Modified residue
41 – 41
N6-succinyllysine; alternate
Modified residue
50 – 50
Phosphoserine
Glycosylation
17 – 17
N-linked (Glc) (glycation) lysine; alternate
Glycosylation
41 – 41
N-linked (Glc) (glycation) lysine; alternate
Helix
22 – 36
Literature citations
A new abnormal human hemoglobin: Hb Prato (alpha 2 31 (B12) Arg leads to Ser beta 2).
Marinucci M.; Mavilio F.; Massa A.; Gabbianelli M.; Fontanarosa P.P.; Camagna A.; Ignesti C.; Tentori L.;
Biochim. Biophys. Acta 578:534-540(1979)
Cited for: VARIANT PRATO SER-32;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.