Variant position: 32 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KAAWGKVGAHAGEYGAEALE RMFLSFPTTKTYFPHF-DLSHG
Gorilla KAAWGKVGAHAGDYGAEALE RMFLSFPTTKTYFPHF-DLSH
Rhesus macaque KAAWGKVGGHAGEYGAEALE RMFLSFPTTKTYFPHF-DLSH
Chimpanzee KAAWGKVGAHAGEYGAEALE RMFLSFPTTKTYFPHF-DLSH
Mouse KAAWGKIGGHGAEYGAEALE RMFASFPTTKTYFPHF-DVSH
Rat KNCWGKIGGHGGEYGEEALQ RMFAAFPTTKTYFSHI-DVSP
Pig KAAWGKVGGQAGAHGAEALE RMFLGFPTTKTYFPHF-NLSH
Bovine KAAWGKVGGHAAEYGAEALE RMFLSFPTTKTYFPHF-DLSH
Rabbit KTAWEKIGSHGGEYGAEAVE RMFLGFPTTKTYFPHF-DFTH
Sheep KAAWGKVGGNAGAYGAEALE RMFLSFPTTKTYFPHF-DLSH
Cat KACWGKIGSHAGEYGAEALE RTFCSFPTTKTYFPHF-DLSH
Horse KAAWSKVGGHAGEYGAEALE RMFLGFPTTKTYFPHF-DLSH
Chicken KGIFTKIAGHAEEYGAETLE RMFTTYPPTKTYFPHF-DLSH
Xenopus tropicalis KAIWPSVAAHGDKYGGEALH RMFMCAPKTKTYFPDF-DFSE
Zebrafish KAIWAKISPKADEIGAEALA RMLTVYPQTKTYFSHWADLSP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
17 – 17 N-linked (Glc) (glycation) lysine; alternate
41 – 41 N-linked (Glc) (glycation) lysine; alternate
22 – 36
A new abnormal human hemoglobin: Hb Prato (alpha 2 31 (B12) Arg leads to Ser beta 2).
Marinucci M.; Mavilio F.; Massa A.; Gabbianelli M.; Fontanarosa P.P.; Camagna A.; Ignesti C.; Tentori L.;
Biochim. Biophys. Acta 578:534-540(1979)
Cited for: VARIANT PRATO SER-32;
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