Variant position: 41 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HAGEYGAEALERMFLSFPTT KTYFPHF-DLSHGSAQVKGHGK
Gorilla HAGDYGAEALERMFLSFPTT KTYFPHF-DLSHGSAQVKGHG
Rhesus macaque HAGEYGAEALERMFLSFPTT KTYFPHF-DLSHGSAQVKGHG
Chimpanzee HAGEYGAEALERMFLSFPTT KTYFPHF-DLSHGSAQVKGHG
Mouse HGAEYGAEALERMFASFPTT KTYFPHF-DVSHGSAQVKGHG
Rat HGGEYGEEALQRMFAAFPTT KTYFSHI-DVSPGSAQVKAHG
Pig QAGAHGAEALERMFLGFPTT KTYFPHF-NLSHGSDQVKAHG
Bovine HAAEYGAEALERMFLSFPTT KTYFPHF-DLSHGSAQVKGHG
Rabbit HGGEYGAEAVERMFLGFPTT KTYFPHF-DFTHGSEQIKAHG
Sheep NAGAYGAEALERMFLSFPTT KTYFPHF-DLSHGSAQVKGHG
Cat HAGEYGAEALERTFCSFPTT KTYFPHF-DLSHGSAQVKAHG
Horse HAGEYGAEALERMFLGFPTT KTYFPHF-DLSHGSAQVKAHG
Chicken HAEEYGAETLERMFTTYPPT KTYFPHF-DLSHGSAQIKGHG
Xenopus tropicalis HGDKYGGEALHRMFMCAPKT KTYFPDF-DFSEHSKHILAHG
Zebrafish KADEIGAEALARMLTVYPQT KTYFSHWADLSPGSGPVKKHG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
38 – 43
Hb Kanagawa [alpha 40(C5)Lys-->Met]: a new alpha chain variant with an increased oxygen affinity.
Miyashita H.; Hashimoto K.; Mohri H.; Ohokubo T.; Harano T.; Harano K.; Imai K.;
Cited for: VARIANT KANAGAWA MET-41;
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