Variant position: 42 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AGEYGAEALERMFLSFPTTK TYFPHF-DLSHGSAQVKGHGKK
Gorilla AGDYGAEALERMFLSFPTTK TYFPHF-DLSHGSAQVKGHGK
Rhesus macaque AGEYGAEALERMFLSFPTTK TYFPHF-DLSHGSAQVKGHGK
Chimpanzee AGEYGAEALERMFLSFPTTK TYFPHF-DLSHGSAQVKGHGK
Mouse GAEYGAEALERMFASFPTTK TYFPHF-DVSHGSAQVKGHGK
Rat GGEYGEEALQRMFAAFPTTK TYFSHI-DVSPGSAQVKAHGK
Pig AGAHGAEALERMFLGFPTTK TYFPHF-NLSHGSDQVKAHGQ
Bovine AAEYGAEALERMFLSFPTTK TYFPHF-DLSHGSAQVKGHGA
Rabbit GGEYGAEAVERMFLGFPTTK TYFPHF-DFTHGSEQIKAHGK
Sheep AGAYGAEALERMFLSFPTTK TYFPHF-DLSHGSAQVKGHGE
Cat AGEYGAEALERTFCSFPTTK TYFPHF-DLSHGSAQVKAHGQ
Horse AGEYGAEALERMFLGFPTTK TYFPHF-DLSHGSAQVKAHGK
Chicken AEEYGAETLERMFTTYPPTK TYFPHF-DLSHGSAQIKGHGK
Xenopus tropicalis GDKYGGEALHRMFMCAPKTK TYFPDF-DFSEHSKHILAHGK
Zebrafish ADEIGAEALARMLTVYPQTK TYFSHWADLSPGSGPVKKHGK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
38 – 43
Hb Miyano or alpha 41(C6)Thr----Ser: a new high oxygen affinity alpha chain variant found in an erythremic blood donor.
Ohba Y.; Imai K.; Uenaka R.; Ami M.; Fujisawa K.; Itoh K.; Hirakawa K.; Miyaji T.;
Cited for: VARIANT MIYANO SER-42;
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