Variant position: 45 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YGAEALERMFLSFPTTKTYF PHF-DLSHGSAQVKGHGKKVAD
Gorilla YGAEALERMFLSFPTTKTYF PHF-DLSHGSAQVKGHGKKVA
Rhesus macaque YGAEALERMFLSFPTTKTYF PHF-DLSHGSAQVKGHGKKVA
Chimpanzee YGAEALERMFLSFPTTKTYF PHF-DLSHGSAQVKGHGKKVA
Mouse YGAEALERMFASFPTTKTYF PHF-DVSHGSAQVKGHGKKVA
Rat YGEEALQRMFAAFPTTKTYF SHI-DVSPGSAQVKAHGKKVA
Pig HGAEALERMFLGFPTTKTYF PHF-NLSHGSDQVKAHGQKVA
Bovine YGAEALERMFLSFPTTKTYF PHF-DLSHGSAQVKGHGAKVA
Rabbit YGAEAVERMFLGFPTTKTYF PHF-DFTHGSEQIKAHGKKVS
Sheep YGAEALERMFLSFPTTKTYF PHF-DLSHGSAQVKGHGEKVA
Cat YGAEALERTFCSFPTTKTYF PHF-DLSHGSAQVKAHGQKVA
Horse YGAEALERMFLGFPTTKTYF PHF-DLSHGSAQVKAHGKKVG
Chicken YGAETLERMFTTYPPTKTYF PHF-DLSHGSAQIKGHGKKVV
Xenopus tropicalis YGGEALHRMFMCAPKTKTYF PDF-DFSEHSKHILAHGKKVS
Zebrafish IGAEALARMLTVYPQTKTYF SHWADLSPGSGPVKKHGKTIM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
45 – 47
Hemoglobin Milledgeville (alpha 44 (CD2) Pro leads to Leu): a new variant with increased oxygen affinity.
Honig G.R.; Vida L.N.; Shamsuddin M.; Mason R.G.; Schlumpf H.W.; Luke R.A.;
Biochim. Biophys. Acta 626:424-431(1980)
Cited for: VARIANT MILLEDGEVILLE LEU-45;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.