Variant position: 46 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GAEALERMFLSFPTTKTYFP HF-DLSHGSAQVKGHGKKVADA
Gorilla GAEALERMFLSFPTTKTYFP HF-DLSHGSAQVKGHGKKVAD
Rhesus macaque GAEALERMFLSFPTTKTYFP HF-DLSHGSAQVKGHGKKVAD
Chimpanzee GAEALERMFLSFPTTKTYFP HF-DLSHGSAQVKGHGKKVAD
Mouse GAEALERMFASFPTTKTYFP HF-DVSHGSAQVKGHGKKVAD
Rat GEEALQRMFAAFPTTKTYFS HI-DVSPGSAQVKAHGKKVAD
Pig GAEALERMFLGFPTTKTYFP HF-NLSHGSDQVKAHGQKVAD
Bovine GAEALERMFLSFPTTKTYFP HF-DLSHGSAQVKGHGAKVAA
Rabbit GAEAVERMFLGFPTTKTYFP HF-DFTHGSEQIKAHGKKVSE
Sheep GAEALERMFLSFPTTKTYFP HF-DLSHGSAQVKGHGEKVAA
Cat GAEALERTFCSFPTTKTYFP HF-DLSHGSAQVKAHGQKVAD
Horse GAEALERMFLGFPTTKTYFP HF-DLSHGSAQVKAHGKKVGD
Chicken GAETLERMFTTYPPTKTYFP HF-DLSHGSAQIKGHGKKVVA
Xenopus tropicalis GGEALHRMFMCAPKTKTYFP DF-DFSEHSKHILAHGKKVSD
Zebrafish GAEALARMLTVYPQTKTYFS HWADLSPGSGPVKKHGKTIMG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
46 – 47 (Microbial infection) Cleavage; by N.americanus apr-2
57 – 57 Not glycated
61 – 61 Not glycated
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
45 – 47
Locus assignment of two alpha-globin structural mutants from the Caribbean basin: alpha Fort de France (alpha 45 Arg) and alpha Spanish Town (alpha 27 Val).
Cash F.E.; Monplaisir N.; Goossens M.; Liebhaber S.A.;
Cited for: VARIANTS SPANISH TOWN VAL-28 AND FORT DE FRANCE ARG-46;
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