Variant position: 48 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EALERMFLSFPTTKTYFPHF- DLSHGSAQVKGHGKKVADALT
Gorilla EALERMFLSFPTTKTYFPHF- DLSHGSAQVKGHGKKVADAL
Rhesus macaque EALERMFLSFPTTKTYFPHF- DLSHGSAQVKGHGKKVADAL
Chimpanzee EALERMFLSFPTTKTYFPHF- DLSHGSAQVKGHGKKVADAL
Mouse EALERMFASFPTTKTYFPHF- DVSHGSAQVKGHGKKVADAL
Rat EALQRMFAAFPTTKTYFSHI- DVSPGSAQVKAHGKKVADAL
Pig EALERMFLGFPTTKTYFPHF- NLSHGSDQVKAHGQKVADAL
Bovine EALERMFLSFPTTKTYFPHF- DLSHGSAQVKGHGAKVAAAL
Rabbit EAVERMFLGFPTTKTYFPHF- DFTHGSEQIKAHGKKVSEAL
Sheep EALERMFLSFPTTKTYFPHF- DLSHGSAQVKGHGEKVAAAL
Cat EALERTFCSFPTTKTYFPHF- DLSHGSAQVKAHGQKVADAL
Horse EALERMFLGFPTTKTYFPHF- DLSHGSAQVKAHGKKVGDAL
Chicken ETLERMFTTYPPTKTYFPHF- DLSHGSAQIKGHGKKVVAAL
Xenopus tropicalis EALHRMFMCAPKTKTYFPDF- DFSEHSKHILAHGKKVSDAL
Zebrafish EALARMLTVYPQTKTYFSHWA DLSPGSGPVKKHGKTIMGAV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
48 – 49 (Microbial infection) Cleavage; by N.americanus apr-2
57 – 57 Not glycated
61 – 61 Not glycated
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
HB Kokura [alpha 47 (CE 5) Asp leads to Gly]: a slightly unstable variant.
Ohba Y.; Hattori Y.; Matsuoka M.; Miyaji T.; Fuyuno K.;
Cited for: VARIANT KOKURA GLY-48;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.