Sequence information
Variant position: 48 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
EALERMFLSFPTTKTYFPHF
D LSHGSAQVKGHGKKVADALT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EALERMFLSFPTTKTYFPHF-D LSHGSAQVKGHGKKVADALT
Gorilla EALERMFLSFPTTKTYFPHF-D LSHGSAQVKGHGKKVADAL
EALDRTFQSFPTTKTYFPHF-D LSPGSAQVKAHGKKVADAL
Rhesus macaque EALERMFLSFPTTKTYFPHF-D LSHGSAQVKGHGKKVADAL
Chimpanzee EALERMFLSFPTTKTYFPHF-D LSHGSAQVKGHGKKVADAL
Mouse EALERMFASFPTTKTYFPHF-D VSHGSAQVKGHGKKVADAL
Rat EALQRMFAAFPTTKTYFSHI-D VSPGSAQVKAHGKKVADAL
Pig EALERMFLGFPTTKTYFPHF-N LSHGSDQVKAHGQKVADAL
Bovine EALERMFLSFPTTKTYFPHF-D LSHGSAQVKGHGAKVAAAL
Rabbit EAVERMFLGFPTTKTYFPHF-D FTHGSEQIKAHGKKVSEAL
Sheep EALERMFLSFPTTKTYFPHF-D LSHGSAQVKGHGEKVAAAL
Cat EALERTFCSFPTTKTYFPHF-D LSHGSAQVKAHGQKVADAL
Horse EALERMFLGFPTTKTYFPHF-D LSHGSAQVKAHGKKVGDAL
Chicken ETLERMFTTYPPTKTYFPHF-D LSHGSAQIKGHGKKVVAAL
Xenopus tropicalis EALHRMFMCAPKTKTYFPDF-D FSEHSKHILAHGKKVSDAL
Zebrafish EALARMLTVYPQTKTYFSHWAD LSPGSGPVKKHGKTIMGAV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
59 – 59
Iron (heme distal ligand)
Site
48 – 49
(Microbial infection) Cleavage; by N.americanus apr-2
Site
57 – 57
Not glycated
Site
61 – 61
Not glycated
Modified residue
36 – 36
Phosphoserine
Modified residue
41 – 41
N6-succinyllysine; alternate
Modified residue
50 – 50
Phosphoserine
Glycosylation
41 – 41
N-linked (Glc) (glycation) lysine; alternate
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Literature citations
HB Kokura [alpha 47 (CE 5) Asp leads to Gly]: a slightly unstable variant.
Ohba Y.; Hattori Y.; Matsuoka M.; Miyaji T.; Fuyuno K.;
Hemoglobin 6:69-74(1982)
Cited for: VARIANT KOKURA GLY-48;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.