Variant position: 51 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ERMFLSFPTTKTYFPHF-DLS HGSAQVKGHGKKVADALTNAV
Gorilla ERMFLSFPTTKTYFPHF-DLS HGSAQVKGHGKKVADALTNA
Rhesus macaque ERMFLSFPTTKTYFPHF-DLS HGSAQVKGHGKKVADALTLA
Chimpanzee ERMFLSFPTTKTYFPHF-DLS HGSAQVKGHGKKVADALTNA
Mouse ERMFASFPTTKTYFPHF-DVS HGSAQVKGHGKKVADALASA
Rat QRMFAAFPTTKTYFSHI-DVS PGSAQVKAHGKKVADALAKA
Pig ERMFLGFPTTKTYFPHF-NLS HGSDQVKAHGQKVADALTKA
Bovine ERMFLSFPTTKTYFPHF-DLS HGSAQVKGHGAKVAAALTKA
Rabbit ERMFLGFPTTKTYFPHF-DFT HGSEQIKAHGKKVSEALTKA
Sheep ERMFLSFPTTKTYFPHF-DLS HGSAQVKGHGEKVAAALTKA
Cat ERTFCSFPTTKTYFPHF-DLS HGSAQVKAHGQKVADALTQA
Horse ERMFLGFPTTKTYFPHF-DLS HGSAQVKAHGKKVGDALTLA
Chicken ERMFTTYPPTKTYFPHF-DLS HGSAQIKGHGKKVVAALIEA
Xenopus tropicalis HRMFMCAPKTKTYFPDF-DFS EHSKHILAHGKKVSDALNEA
Zebrafish ARMLTVYPQTKTYFSHWADLS PGSGPVKKHGKTIMGAVGEA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
50 – 52
Hemoglobin Aichi [alpha 50(CE8) His----Arg]: a new slightly unstable hemoglobin variant discovered in Japan.
Harano T.; Harano K.; Shibata S.; Ueda S.; Mori H.; Seki M.;
FEBS Lett. 169:297-299(1984)
Cited for: VARIANT AICHI ARG-51;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.