Variant position: 55 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSFPTTKTYFPHF-DLSHGSA QVKGHGKKVADALTNAVAHVD
Gorilla LSFPTTKTYFPHF-DLSHGSA QVKGHGKKVADALTNAVAHV
Rhesus macaque LSFPTTKTYFPHF-DLSHGSA QVKGHGKKVADALTLAVGHV
Chimpanzee LSFPTTKTYFPHF-DLSHGSA QVKGHGKKVADALTNAVAHV
Mouse ASFPTTKTYFPHF-DVSHGSA QVKGHGKKVADALASAAGHL
Rat AAFPTTKTYFSHI-DVSPGSA QVKAHGKKVADALAKAADHV
Pig LGFPTTKTYFPHF-NLSHGSD QVKAHGQKVADALTKAVGHL
Bovine LSFPTTKTYFPHF-DLSHGSA QVKGHGAKVAAALTKAVEHL
Rabbit LGFPTTKTYFPHF-DFTHGSE QIKAHGKKVSEALTKAVGHL
Sheep LSFPTTKTYFPHF-DLSHGSA QVKGHGEKVAAALTKAVGHL
Cat CSFPTTKTYFPHF-DLSHGSA QVKAHGQKVADALTQAVAHM
Horse LGFPTTKTYFPHF-DLSHGSA QVKAHGKKVGDALTLAVGHL
Chicken TTYPPTKTYFPHF-DLSHGSA QIKGHGKKVVAALIEAANHI
Xenopus tropicalis MCAPKTKTYFPDF-DFSEHSK HILAHGKKVSDALNEACNHL
Zebrafish TVYPQTKTYFSHWADLSPGSG PVKKHGKTIMGAVGEAISKI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
54 – 72
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.