Variant position: 57 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FPTTKTYFPHF-DLSHGSAQV KGHGKKVADALTNAVAHVDDM
Gorilla FPTTKTYFPHF-DLSHGSAQV KGHGKKVADALTNAVAHVDD
Rhesus macaque FPTTKTYFPHF-DLSHGSAQV KGHGKKVADALTLAVGHVDD
Chimpanzee FPTTKTYFPHF-DLSHGSAQV KGHGKKVADALTNAVAHVDD
Mouse FPTTKTYFPHF-DVSHGSAQV KGHGKKVADALASAAGHLDD
Rat FPTTKTYFSHI-DVSPGSAQV KAHGKKVADALAKAADHVED
Pig FPTTKTYFPHF-NLSHGSDQV KAHGQKVADALTKAVGHLDD
Bovine FPTTKTYFPHF-DLSHGSAQV KGHGAKVAAALTKAVEHLDD
Rabbit FPTTKTYFPHF-DFTHGSEQI KAHGKKVSEALTKAVGHLDD
Sheep FPTTKTYFPHF-DLSHGSAQV KGHGEKVAAALTKAVGHLDD
Cat FPTTKTYFPHF-DLSHGSAQV KAHGQKVADALTQAVAHMDD
Horse FPTTKTYFPHF-DLSHGSAQV KAHGKKVGDALTLAVGHLDD
Chicken YPPTKTYFPHF-DLSHGSAQI KGHGKKVVAALIEAANHIDD
Xenopus tropicalis APKTKTYFPDF-DFSEHSKHI LAHGKKVSDALNEACNHLDN
Zebrafish YPQTKTYFSHWADLSPGSGPV KKHGKTIMGAVGEAISKIDD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
56 – 57 (Microbial infection) Cleavage; by N.americanus apr-2
57 – 57 Not glycated
61 – 61 Not glycated
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
54 – 72
Hb Port Huron [alpha 56 (E5)Lys-->Arg]: a new alpha chain variant.
Zwerdling T.; Williams S.; Nasr S.A.; Rucknagel D.L.;
Cited for: VARIANT PORT HURON ARG-57;
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