Variant position: 59 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TTKTYFPHF-DLSHGSAQVKG HGKKVADALTNAVAHVDDMPN
Gorilla TTKTYFPHF-DLSHGSAQVKG HGKKVADALTNAVAHVDDMP
Rhesus macaque TTKTYFPHF-DLSHGSAQVKG HGKKVADALTLAVGHVDDMP
Chimpanzee TTKTYFPHF-DLSHGSAQVKG HGKKVADALTNAVAHVDDMP
Mouse TTKTYFPHF-DVSHGSAQVKG HGKKVADALASAAGHLDDLP
Rat TTKTYFSHI-DVSPGSAQVKA HGKKVADALAKAADHVEDLP
Pig TTKTYFPHF-NLSHGSDQVKA HGQKVADALTKAVGHLDDLP
Bovine TTKTYFPHF-DLSHGSAQVKG HGAKVAAALTKAVEHLDDLP
Rabbit TTKTYFPHF-DFTHGSEQIKA HGKKVSEALTKAVGHLDDLP
Sheep TTKTYFPHF-DLSHGSAQVKG HGEKVAAALTKAVGHLDDLP
Cat TTKTYFPHF-DLSHGSAQVKA HGQKVADALTQAVAHMDDLP
Horse TTKTYFPHF-DLSHGSAQVKA HGKKVGDALTLAVGHLDDLP
Chicken PTKTYFPHF-DLSHGSAQIKG HGKKVVAALIEAANHIDDIA
Xenopus tropicalis KTKTYFPDF-DFSEHSKHILA HGKKVSDALNEACNHLDNIA
Zebrafish QTKTYFSHWADLSPGSGPVKK HGKTIMGAVGEAISKIDDLV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
54 – 72
Structure of hemoglobin M Boston, a variant with a five-coordinated ferric heme.
Pulsinelli P.D.; Perutz M.F.; Nagel R.L.;
Proc. Natl. Acad. Sci. U.S.A. 70:3870-3874(1973)
Cited for: VARIANT M-BOSTON/M-OSAKA TYR-59;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.