Variant position: 61 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KTYFPHF-DLSHGSAQVKGHG KKVADALTNAVAHVDDMPNAL
Gorilla KTYFPHF-DLSHGSAQVKGHG KKVADALTNAVAHVDDMPNA
Rhesus macaque KTYFPHF-DLSHGSAQVKGHG KKVADALTLAVGHVDDMPNA
Chimpanzee KTYFPHF-DLSHGSAQVKGHG KKVADALTNAVAHVDDMPNA
Mouse KTYFPHF-DVSHGSAQVKGHG KKVADALASAAGHLDDLPGA
Rat KTYFSHI-DVSPGSAQVKAHG KKVADALAKAADHVEDLPGA
Pig KTYFPHF-NLSHGSDQVKAHG QKVADALTKAVGHLDDLPGA
Bovine KTYFPHF-DLSHGSAQVKGHG AKVAAALTKAVEHLDDLPGA
Rabbit KTYFPHF-DFTHGSEQIKAHG KKVSEALTKAVGHLDDLPGA
Sheep KTYFPHF-DLSHGSAQVKGHG EKVAAALTKAVGHLDDLPGT
Cat KTYFPHF-DLSHGSAQVKAHG QKVADALTQAVAHMDDLPTA
Horse KTYFPHF-DLSHGSAQVKAHG KKVGDALTLAVGHLDDLPGA
Chicken KTYFPHF-DLSHGSAQIKGHG KKVVAALIEAANHIDDIAGT
Xenopus tropicalis KTYFPDF-DFSEHSKHILAHG KKVSDALNEACNHLDNIAGC
Zebrafish KTYFSHWADLSPGSGPVKKHG KTIMGAVGEAISKIDDLVGG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
57 – 57 Not glycated
60 – 61 (Microbial infection) Cleavage; by N.americanus apr-2
61 – 61 Not glycated
41 – 41 N6-succinyllysine; alternate
50 – 50 Phosphoserine
41 – 41 N-linked (Glc) (glycation) lysine; alternate
62 – 62 N-linked (Glc) (glycation) lysine
54 – 72
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.