Variant position: 62 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TYFPHF-DLSHGSAQVKGHGK KVADALTNAVAHVDDMPNALS
Gorilla TYFPHF-DLSHGSAQVKGHGK KVADALTNAVAHVDDMPNAL
Rhesus macaque TYFPHF-DLSHGSAQVKGHGK KVADALTLAVGHVDDMPNAL
Chimpanzee TYFPHF-DLSHGSAQVKGHGK KVADALTNAVAHVDDMPNAL
Mouse TYFPHF-DVSHGSAQVKGHGK KVADALASAAGHLDDLPGAL
Rat TYFSHI-DVSPGSAQVKAHGK KVADALAKAADHVEDLPGAL
Pig TYFPHF-NLSHGSDQVKAHGQ KVADALTKAVGHLDDLPGAL
Bovine TYFPHF-DLSHGSAQVKGHGA KVAAALTKAVEHLDDLPGAL
Rabbit TYFPHF-DFTHGSEQIKAHGK KVSEALTKAVGHLDDLPGAL
Sheep TYFPHF-DLSHGSAQVKGHGE KVAAALTKAVGHLDDLPGTL
Cat TYFPHF-DLSHGSAQVKAHGQ KVADALTQAVAHMDDLPTAM
Horse TYFPHF-DLSHGSAQVKAHGK KVGDALTLAVGHLDDLPGAL
Chicken TYFPHF-DLSHGSAQIKGHGK KVVAALIEAANHIDDIAGTL
Xenopus tropicalis TYFPDF-DFSEHSKHILAHGK KVSDALNEACNHLDNIAGCL
Zebrafish TYFSHWADLSPGSGPVKKHGK TIMGAVGEAISKIDDLVGGL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
50 – 50 Phosphoserine
62 – 62 N-linked (Glc) (glycation) lysine
54 – 72
Structural characterizations of hemoglobins J-Buda (alpha 61 (E10) Lys-to-Asn) and G-Pest (alpha 74 (EF3) Asp-to-Asn).
Brimhall B.J.; Duerst M.; Hollan S.R.; Stenzel P.; Szelenyi J.; Jones R.T.;
Cited for: VARIANTS J-BUDA ASN-62 AND G-PEST ASN-75;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.