Sequence information
Variant position: 62 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
TYFPHFDLSHGSAQVKGHGK
K VADALTNAVAHVDDMPNALS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TYFPHF-DLSHGSAQVKGHGKK VADALTNAVAHVDDMPNALS
Gorilla TYFPHF-DLSHGSAQVKGHGKK VADALTNAVAHVDDMPNAL
TYFPHF-DLSPGSAQVKAHGKK VADALTTAVAHLDDLPGAL
Rhesus macaque TYFPHF-DLSHGSAQVKGHGKK VADALTLAVGHVDDMPNAL
Chimpanzee TYFPHF-DLSHGSAQVKGHGKK VADALTNAVAHVDDMPNAL
Mouse TYFPHF-DVSHGSAQVKGHGKK VADALASAAGHLDDLPGAL
Rat TYFSHI-DVSPGSAQVKAHGKK VADALAKAADHVEDLPGAL
Pig TYFPHF-NLSHGSDQVKAHGQK VADALTKAVGHLDDLPGAL
Bovine TYFPHF-DLSHGSAQVKGHGAK VAAALTKAVEHLDDLPGAL
Rabbit TYFPHF-DFTHGSEQIKAHGKK VSEALTKAVGHLDDLPGAL
Sheep TYFPHF-DLSHGSAQVKGHGEK VAAALTKAVGHLDDLPGTL
Cat TYFPHF-DLSHGSAQVKAHGQK VADALTQAVAHMDDLPTAM
Horse TYFPHF-DLSHGSAQVKAHGKK VGDALTLAVGHLDDLPGAL
Chicken TYFPHF-DLSHGSAQIKGHGKK VVAALIEAANHIDDIAGTL
Xenopus tropicalis TYFPDF-DFSEHSKHILAHGKK VSDALNEACNHLDNIAGCL
Zebrafish TYFSHWADLSPGSGPVKKHGKT IMGAVGEAISKIDDLVGGL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
59 – 59
Iron (heme b distal ligand)
Site
57 – 57
Not glycated
Site
61 – 61
Not glycated
Modified residue
50 – 50
Phosphoserine
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Helix
54 – 72
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.