Sequence information
Variant position: 65 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
PHFDLSHGSAQVKGHGKKVA
D ALTNAVAHVDDMPNALSALS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PHF-DLSHGSAQVKGHGKKVAD ALTNAVAHVDDMPNALSALS
Gorilla PHF-DLSHGSAQVKGHGKKVAD ALTNAVAHVDDMPNALSAL
PHF-DLSPGSAQVKAHGKKVAD ALTTAVAHLDDLPGALSAL
Rhesus macaque PHF-DLSHGSAQVKGHGKKVAD ALTLAVGHVDDMPNALSAL
Chimpanzee PHF-DLSHGSAQVKGHGKKVAD ALTNAVAHVDDMPNALSAL
Mouse PHF-DVSHGSAQVKGHGKKVAD ALASAAGHLDDLPGALSAL
Rat SHI-DVSPGSAQVKAHGKKVAD ALAKAADHVEDLPGALSTL
Pig PHF-NLSHGSDQVKAHGQKVAD ALTKAVGHLDDLPGALSAL
Bovine PHF-DLSHGSAQVKGHGAKVAA ALTKAVEHLDDLPGALSEL
Rabbit PHF-DFTHGSEQIKAHGKKVSE ALTKAVGHLDDLPGALSTL
Sheep PHF-DLSHGSAQVKGHGEKVAA ALTKAVGHLDDLPGTLSDL
Cat PHF-DLSHGSAQVKAHGQKVAD ALTQAVAHMDDLPTAMSAL
Horse PHF-DLSHGSAQVKAHGKKVGD ALTLAVGHLDDLPGALSNL
Chicken PHF-DLSHGSAQIKGHGKKVVA ALIEAANHIDDIAGTLSKL
Xenopus tropicalis PDF-DFSEHSKHILAHGKKVSD ALNEACNHLDNIAGCLSKL
Zebrafish SHWADLSPGSGPVKKHGKTIMG AVGEAISKIDDLVGGLAAL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
59 – 59
Iron (heme b distal ligand)
Site
57 – 57
Not glycated
Site
61 – 61
Not glycated
Modified residue
50 – 50
Phosphoserine
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Helix
54 – 72
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.