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UniProtKB/Swiss-Prot P69905: Variant p.Asp65Tyr

Hemoglobin subunit alpha
Gene: HBA2
Variant information

Variant position:  65
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Aspartate (D) to Tyrosine (Y) at position 65 (D65Y, p.Asp65Tyr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (D) to large size and aromatic (Y)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In Persepolis.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  65
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  142
The length of the canonical sequence.

Location on the sequence:   PHFDLSHGSAQVKGHGKKVA  D ALTNAVAHVDDMPNALSALS
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         PHF-DLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALS

Gorilla                       PHF-DLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSAL

                              PHF-DLSPGSAQVKAHGKKVADALTTAVAHLDDLPGALSAL

Rhesus macaque                PHF-DLSHGSAQVKGHGKKVADALTLAVGHVDDMPNALSAL

Chimpanzee                    PHF-DLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSAL

Mouse                         PHF-DVSHGSAQVKGHGKKVADALASAAGHLDDLPGALSAL

Rat                           SHI-DVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTL

Pig                           PHF-NLSHGSDQVKAHGQKVADALTKAVGHLDDLPGALSAL

Bovine                        PHF-DLSHGSAQVKGHGAKVAAALTKAVEHLDDLPGALSEL

Rabbit                        PHF-DFTHGSEQIKAHGKKVSEALTKAVGHLDDLPGALSTL

Sheep                         PHF-DLSHGSAQVKGHGEKVAAALTKAVGHLDDLPGTLSDL

Cat                           PHF-DLSHGSAQVKAHGQKVADALTQAVAHMDDLPTAMSAL

Horse                         PHF-DLSHGSAQVKAHGKKVGDALTLAVGHLDDLPGALSNL

Chicken                       PHF-DLSHGSAQIKGHGKKVVAALIEAANHIDDIAGTLSKL

Xenopus tropicalis            PDF-DFSEHSKHILAHGKKVSDALNEACNHLDNIAGCLSKL

Zebrafish                     SHWADLSPGSGPVKKHGKTIMGAVGEAISKIDDLVGGLAAL

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Metal binding 59 – 59 Iron (heme distal ligand)
Site 57 – 57 Not glycated
Site 61 – 61 Not glycated
Modified residue 50 – 50 Phosphoserine
Glycosylation 62 – 62 N-linked (Glc) (glycation) lysine
Helix 54 – 72


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.