Sequence information
Variant position: 72 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
GSAQVKGHGKKVADALTNAV
A HVDDMPNALSALSDLHAHKL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSAQVKGHGKKVADALTNAVA HVDDMPNALSALSDLHAHKL
Gorilla GSAQVKGHGKKVADALTNAVA HVDDMPNALSALSDLHAHKL
GSAQVKAHGKKVADALTTAVA HLDDLPGALSALSDLHAYKL
Rhesus macaque GSAQVKGHGKKVADALTLAVG HVDDMPNALSALSDLHAHKL
Chimpanzee GSAQVKGHGKKVADALTNAVA HVDDMPNALSALSDLHAHKL
Mouse GSAQVKGHGKKVADALASAAG HLDDLPGALSALSDLHAHKL
Rat GSAQVKAHGKKVADALAKAAD HVEDLPGALSTLSDLHAHKL
Pig GSDQVKAHGQKVADALTKAVG HLDDLPGALSALSDLHAHKL
Bovine GSAQVKGHGAKVAAALTKAVE HLDDLPGALSELSDLHAHKL
Rabbit GSEQIKAHGKKVSEALTKAVG HLDDLPGALSTLSDLHAHKL
Sheep GSAQVKGHGEKVAAALTKAVG HLDDLPGTLSDLSDLHAHKL
Cat GSAQVKAHGQKVADALTQAVA HMDDLPTAMSALSDLHAYKL
Horse GSAQVKAHGKKVGDALTLAVG HLDDLPGALSNLSDLHAHKL
Chicken GSAQIKGHGKKVVAALIEAAN HIDDIAGTLSKLSDLHAHKL
Xenopus tropicalis HSKHILAHGKKVSDALNEACN HLDNIAGCLSKLSDLHAYDL
Zebrafish GSGPVKKHGKTIMGAVGEAIS KIDDLVGGLAALSELHAFKL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
59 – 59
Iron (heme b distal ligand)
Metal binding
88 – 88
Iron (heme b proximal ligand)
Site
57 – 57
Not glycated
Site
61 – 61
Not glycated
Site
91 – 91
Not glycated
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Helix
54 – 72
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.