Variant position: 72 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSAQVKGHGKKVADALTNAV AHVDDMPNALSALSDLHAHKL
Gorilla GSAQVKGHGKKVADALTNAV AHVDDMPNALSALSDLHAHKL
Rhesus macaque GSAQVKGHGKKVADALTLAV GHVDDMPNALSALSDLHAHKL
Chimpanzee GSAQVKGHGKKVADALTNAV AHVDDMPNALSALSDLHAHKL
Mouse GSAQVKGHGKKVADALASAA GHLDDLPGALSALSDLHAHKL
Rat GSAQVKAHGKKVADALAKAA DHVEDLPGALSTLSDLHAHKL
Pig GSDQVKAHGQKVADALTKAV GHLDDLPGALSALSDLHAHKL
Bovine GSAQVKGHGAKVAAALTKAV EHLDDLPGALSELSDLHAHKL
Rabbit GSEQIKAHGKKVSEALTKAV GHLDDLPGALSTLSDLHAHKL
Sheep GSAQVKGHGEKVAAALTKAV GHLDDLPGTLSDLSDLHAHKL
Cat GSAQVKAHGQKVADALTQAV AHMDDLPTAMSALSDLHAYKL
Horse GSAQVKAHGKKVGDALTLAV GHLDDLPGALSNLSDLHAHKL
Chicken GSAQIKGHGKKVVAALIEAA NHIDDIAGTLSKLSDLHAHKL
Xenopus tropicalis HSKHILAHGKKVSDALNEAC NHLDNIAGCLSKLSDLHAYDL
Zebrafish GSGPVKKHGKTIMGAVGEAI SKIDDLVGGLAALSELHAFKL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
88 – 88 Iron (heme b proximal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
91 – 91 Not glycated
62 – 62 N-linked (Glc) (glycation) lysine
54 – 72
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.