Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SAQVKGHGKKVADALTNAVA HVDDMPNALSALSDLHAHKLR
Gorilla SAQVKGHGKKVADALTNAVA HVDDMPNALSALSDLHAHKLR
Rhesus macaque SAQVKGHGKKVADALTLAVG HVDDMPNALSALSDLHAHKLR
Chimpanzee SAQVKGHGKKVADALTNAVA HVDDMPNALSALSDLHAHKLR
Mouse SAQVKGHGKKVADALASAAG HLDDLPGALSALSDLHAHKLR
Rat SAQVKAHGKKVADALAKAAD HVEDLPGALSTLSDLHAHKLR
Pig SDQVKAHGQKVADALTKAVG HLDDLPGALSALSDLHAHKLR
Bovine SAQVKGHGAKVAAALTKAVE HLDDLPGALSELSDLHAHKLR
Rabbit SEQIKAHGKKVSEALTKAVG HLDDLPGALSTLSDLHAHKLR
Sheep SAQVKGHGEKVAAALTKAVG HLDDLPGTLSDLSDLHAHKLR
Cat SAQVKAHGQKVADALTQAVA HMDDLPTAMSALSDLHAYKLR
Horse SAQVKAHGKKVGDALTLAVG HLDDLPGALSNLSDLHAHKLR
Chicken SAQIKGHGKKVVAALIEAAN HIDDIAGTLSKLSDLHAHKLR
Xenopus tropicalis SKHILAHGKKVSDALNEACN HLDNIAGCLSKLSDLHAYDLR
Zebrafish SGPVKKHGKTIMGAVGEAIS KIDDLVGGLAALSELHAFKLR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme distal ligand)
88 – 88 Iron (heme proximal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
91 – 91 Not glycated
62 – 62 N-linked (Glc) (glycation) lysine
73 – 75
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.