Sequence information
Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
SAQVKGHGKKVADALTNAVA
H VDDMPNALSALSDLHAHKLR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SAQVKGHGKKVADALTNAVAH VDDMPNALSALSDLHAHKLR
Gorilla SAQVKGHGKKVADALTNAVAH VDDMPNALSALSDLHAHKLR
SAQVKAHGKKVADALTTAVAH LDDLPGALSALSDLHAYKLR
Rhesus macaque SAQVKGHGKKVADALTLAVGH VDDMPNALSALSDLHAHKLR
Chimpanzee SAQVKGHGKKVADALTNAVAH VDDMPNALSALSDLHAHKLR
Mouse SAQVKGHGKKVADALASAAGH LDDLPGALSALSDLHAHKLR
Rat SAQVKAHGKKVADALAKAADH VEDLPGALSTLSDLHAHKLR
Pig SDQVKAHGQKVADALTKAVGH LDDLPGALSALSDLHAHKLR
Bovine SAQVKGHGAKVAAALTKAVEH LDDLPGALSELSDLHAHKLR
Rabbit SEQIKAHGKKVSEALTKAVGH LDDLPGALSTLSDLHAHKLR
Sheep SAQVKGHGEKVAAALTKAVGH LDDLPGTLSDLSDLHAHKLR
Cat SAQVKAHGQKVADALTQAVAH MDDLPTAMSALSDLHAYKLR
Horse SAQVKAHGKKVGDALTLAVGH LDDLPGALSNLSDLHAHKLR
Chicken SAQIKGHGKKVVAALIEAANH IDDIAGTLSKLSDLHAHKLR
Xenopus tropicalis SKHILAHGKKVSDALNEACNH LDNIAGCLSKLSDLHAYDLR
Zebrafish SGPVKKHGKTIMGAVGEAISK IDDLVGGLAALSELHAFKLR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
59 – 59
Iron (heme b distal ligand)
Metal binding
88 – 88
Iron (heme b proximal ligand)
Site
57 – 57
Not glycated
Site
61 – 61
Not glycated
Site
91 – 91
Not glycated
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Turn
73 – 75
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.