Variant position: 75 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QVKGHGKKVADALTNAVAHV DDMPNALSALSDLHAHKLRVD
Gorilla QVKGHGKKVADALTNAVAHV DDMPNALSALSDLHAHKLRVD
Rhesus macaque QVKGHGKKVADALTLAVGHV DDMPNALSALSDLHAHKLRVD
Chimpanzee QVKGHGKKVADALTNAVAHV DDMPNALSALSDLHAHKLRVD
Mouse QVKGHGKKVADALASAAGHL DDLPGALSALSDLHAHKLRVD
Rat QVKAHGKKVADALAKAADHV EDLPGALSTLSDLHAHKLRVD
Pig QVKAHGQKVADALTKAVGHL DDLPGALSALSDLHAHKLRVD
Bovine QVKGHGAKVAAALTKAVEHL DDLPGALSELSDLHAHKLRVD
Rabbit QIKAHGKKVSEALTKAVGHL DDLPGALSTLSDLHAHKLRVD
Sheep QVKGHGEKVAAALTKAVGHL DDLPGTLSDLSDLHAHKLRVD
Cat QVKAHGQKVADALTQAVAHM DDLPTAMSALSDLHAYKLRVD
Horse QVKAHGKKVGDALTLAVGHL DDLPGALSNLSDLHAHKLRVD
Chicken QIKGHGKKVVAALIEAANHI DDIAGTLSKLSDLHAHKLRVD
Xenopus tropicalis HILAHGKKVSDALNEACNHL DNIAGCLSKLSDLHAYDLRVD
Zebrafish PVKKHGKTIMGAVGEAISKI DDLVGGLAALSELHAFKLRVD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
88 – 88 Iron (heme b proximal ligand)
57 – 57 Not glycated
61 – 61 Not glycated
91 – 91 Not glycated
62 – 62 N-linked (Glc) (glycation) lysine
73 – 75
Structural characterizations of hemoglobins J-Buda (alpha 61 (E10) Lys-to-Asn) and G-Pest (alpha 74 (EF3) Asp-to-Asn).
Brimhall B.J.; Duerst M.; Hollan S.R.; Stenzel P.; Szelenyi J.; Jones R.T.;
Cited for: VARIANTS J-BUDA ASN-62 AND G-PEST ASN-75;
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