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UniProtKB/Swiss-Prot P69905: Variant p.Met77Thr

Hemoglobin subunit alpha
Gene: HBA2
Chromosomal location: 16p13.3
Variant information

Variant position:  77
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Methionine (M) to Threonine (T) at position 77 (M77T, p.Met77Thr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and hydrophobic (M) to medium size and polar (T)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In Aztec.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  77
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  142
The length of the canonical sequence.

Location on the sequence:   KGHGKKVADALTNAVAHVDD  M PNALSALSDLHAHKLRVDPV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPV

Gorilla                       KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPV

                              KAHGKKVADALTTAVAHLDDLPGALSALSDLHAYKLRVDPV

Rhesus macaque                KGHGKKVADALTLAVGHVDDMPNALSALSDLHAHKLRVDPV

Chimpanzee                    KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPV

Mouse                         KGHGKKVADALASAAGHLDDLPGALSALSDLHAHKLRVDPV

Rat                           KAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPV

Pig                           KAHGQKVADALTKAVGHLDDLPGALSALSDLHAHKLRVDPV

Bovine                        KGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPV

Rabbit                        KAHGKKVSEALTKAVGHLDDLPGALSTLSDLHAHKLRVDPV

Sheep                         KGHGEKVAAALTKAVGHLDDLPGTLSDLSDLHAHKLRVDPV

Cat                           KAHGQKVADALTQAVAHMDDLPTAMSALSDLHAYKLRVDPV

Horse                         KAHGKKVGDALTLAVGHLDDLPGALSNLSDLHAHKLRVDPV

Chicken                       KGHGKKVVAALIEAANHIDDIAGTLSKLSDLHAHKLRVDPV

Xenopus tropicalis            LAHGKKVSDALNEACNHLDNIAGCLSKLSDLHAYDLRVDPG

Zebrafish                     KKHGKTIMGAVGEAISKIDDLVGGLAALSELHAFKLRVDPA

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Metal binding 59 – 59 Iron (heme distal ligand)
Metal binding 88 – 88 Iron (heme proximal ligand)
Site 57 – 57 Not glycated
Site 61 – 61 Not glycated
Site 91 – 91 Not glycated
Glycosylation 62 – 62 N-linked (Glc) (glycation) lysine
Helix 77 – 80


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.