Variant position: 78 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GHGKKVADALTNAVAHVDDM PNALSALSDLHAHKLRVDPVN
Gorilla GHGKKVADALTNAVAHVDDM PNALSALSDLHAHKLRVDPVN
Rhesus macaque GHGKKVADALTLAVGHVDDM PNALSALSDLHAHKLRVDPVN
Chimpanzee GHGKKVADALTNAVAHVDDM PNALSALSDLHAHKLRVDPVN
Mouse GHGKKVADALASAAGHLDDL PGALSALSDLHAHKLRVDPVN
Rat AHGKKVADALAKAADHVEDL PGALSTLSDLHAHKLRVDPVN
Pig AHGQKVADALTKAVGHLDDL PGALSALSDLHAHKLRVDPVN
Bovine GHGAKVAAALTKAVEHLDDL PGALSELSDLHAHKLRVDPVN
Rabbit AHGKKVSEALTKAVGHLDDL PGALSTLSDLHAHKLRVDPVN
Sheep GHGEKVAAALTKAVGHLDDL PGTLSDLSDLHAHKLRVDPVN
Cat AHGQKVADALTQAVAHMDDL PTAMSALSDLHAYKLRVDPVN
Horse AHGKKVGDALTLAVGHLDDL PGALSNLSDLHAHKLRVDPVN
Chicken GHGKKVVAALIEAANHIDDI AGTLSKLSDLHAHKLRVDPVN
Xenopus tropicalis AHGKKVSDALNEACNHLDNI AGCLSKLSDLHAYDLRVDPGN
Zebrafish KHGKTIMGAVGEAISKIDDL VGGLAALSELHAFKLRVDPAN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
88 – 88 Iron (heme b proximal ligand)
61 – 61 Not glycated
91 – 91 Not glycated
62 – 62 N-linked (Glc) (glycation) lysine
77 – 80
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.