Variant position: 79 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HGKKVADALTNAVAHVDDMP NALSALSDLHAHKLRVDPVNF
Gorilla HGKKVADALTNAVAHVDDMP NALSALSDLHAHKLRVDPVNF
Rhesus macaque HGKKVADALTLAVGHVDDMP NALSALSDLHAHKLRVDPVNF
Chimpanzee HGKKVADALTNAVAHVDDMP NALSALSDLHAHKLRVDPVNF
Mouse HGKKVADALASAAGHLDDLP GALSALSDLHAHKLRVDPVNF
Rat HGKKVADALAKAADHVEDLP GALSTLSDLHAHKLRVDPVNF
Pig HGQKVADALTKAVGHLDDLP GALSALSDLHAHKLRVDPVNF
Bovine HGAKVAAALTKAVEHLDDLP GALSELSDLHAHKLRVDPVNF
Rabbit HGKKVSEALTKAVGHLDDLP GALSTLSDLHAHKLRVDPVNF
Sheep HGEKVAAALTKAVGHLDDLP GTLSDLSDLHAHKLRVDPVNF
Cat HGQKVADALTQAVAHMDDLP TAMSALSDLHAYKLRVDPVNF
Horse HGKKVGDALTLAVGHLDDLP GALSNLSDLHAHKLRVDPVNF
Chicken HGKKVVAALIEAANHIDDIA GTLSKLSDLHAHKLRVDPVNF
Xenopus tropicalis HGKKVSDALNEACNHLDNIA GCLSKLSDLHAYDLRVDPGNF
Zebrafish HGKTIMGAVGEAISKIDDLV GGLAALSELHAFKLRVDPANF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
59 – 59 Iron (heme b distal ligand)
88 – 88 Iron (heme b proximal ligand)
61 – 61 Not glycated
91 – 91 Not glycated
62 – 62 N-linked (Glc) (glycation) lysine
77 – 80
Hb Davenport or alpha 2(78)(EF7)Asn-->His beta 2.
Wilson J.B.; Webber B.B.; Plaseska D.; de Alarcon P.A.; McMillan S.K.; Huisman T.H.J.;
Cited for: VARIANT DAVENPORT HIS-79;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.