Sequence information
Variant position: 79 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
HGKKVADALTNAVAHVDDMP
N ALSALSDLHAHKLRVDPVNF
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HGKKVADALTNAVAHVDDMPN ALSALSDLHAHKLRVDPVNF
Gorilla HGKKVADALTNAVAHVDDMPN ALSALSDLHAHKLRVDPVNF
HGKKVADALTTAVAHLDDLPG ALSALSDLHAYKLRVDPVNF
Rhesus macaque HGKKVADALTLAVGHVDDMPN ALSALSDLHAHKLRVDPVNF
Chimpanzee HGKKVADALTNAVAHVDDMPN ALSALSDLHAHKLRVDPVNF
Mouse HGKKVADALASAAGHLDDLPG ALSALSDLHAHKLRVDPVNF
Rat HGKKVADALAKAADHVEDLPG ALSTLSDLHAHKLRVDPVNF
Pig HGQKVADALTKAVGHLDDLPG ALSALSDLHAHKLRVDPVNF
Bovine HGAKVAAALTKAVEHLDDLPG ALSELSDLHAHKLRVDPVNF
Rabbit HGKKVSEALTKAVGHLDDLPG ALSTLSDLHAHKLRVDPVNF
Sheep HGEKVAAALTKAVGHLDDLPG TLSDLSDLHAHKLRVDPVNF
Cat HGQKVADALTQAVAHMDDLPT AMSALSDLHAYKLRVDPVNF
Horse HGKKVGDALTLAVGHLDDLPG ALSNLSDLHAHKLRVDPVNF
Chicken HGKKVVAALIEAANHIDDIAG TLSKLSDLHAHKLRVDPVNF
Xenopus tropicalis HGKKVSDALNEACNHLDNIAG CLSKLSDLHAYDLRVDPGNF
Zebrafish HGKTIMGAVGEAISKIDDLVG GLAALSELHAFKLRVDPANF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
59 – 59
Iron (heme b distal ligand)
Metal binding
88 – 88
Iron (heme b proximal ligand)
Site
61 – 61
Not glycated
Site
91 – 91
Not glycated
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Helix
77 – 80
Literature citations
Hb Davenport or alpha 2(78)(EF7)Asn-->His beta 2.
Wilson J.B.; Webber B.B.; Plaseska D.; de Alarcon P.A.; McMillan S.K.; Huisman T.H.J.;
Hemoglobin 14:599-605(1990)
Cited for: VARIANT DAVENPORT HIS-79;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.