Sequence information
Variant position: 81 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
KKVADALTNAVAHVDDMPNA
L SALSDLHAHKLRVDPVNFKL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKL
Gorilla KKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKL
KKVADALTTAVAHLDDLPGAL SALSDLHAYKLRVDPVNFKL
Rhesus macaque KKVADALTLAVGHVDDMPNAL SALSDLHAHKLRVDPVNFKL
Chimpanzee KKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKL
Mouse KKVADALASAAGHLDDLPGAL SALSDLHAHKLRVDPVNFKL
Rat KKVADALAKAADHVEDLPGAL STLSDLHAHKLRVDPVNFKF
Pig QKVADALTKAVGHLDDLPGAL SALSDLHAHKLRVDPVNFKL
Bovine AKVAAALTKAVEHLDDLPGAL SELSDLHAHKLRVDPVNFKL
Rabbit KKVSEALTKAVGHLDDLPGAL STLSDLHAHKLRVDPVNFKL
Sheep EKVAAALTKAVGHLDDLPGTL SDLSDLHAHKLRVDPVNFKL
Cat QKVADALTQAVAHMDDLPTAM SALSDLHAYKLRVDPVNFKF
Horse KKVGDALTLAVGHLDDLPGAL SNLSDLHAHKLRVDPVNFKL
Chicken KKVVAALIEAANHIDDIAGTL SKLSDLHAHKLRVDPVNFKL
Xenopus tropicalis KKVSDALNEACNHLDNIAGCL SKLSDLHAYDLRVDPGNFPL
Zebrafish KTIMGAVGEAISKIDDLVGGL AALSELHAFKLRVDPANFKI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
88 – 88
Iron (heme b proximal ligand)
Site
61 – 61
Not glycated
Site
91 – 91
Not glycated
Site
100 – 100
Not glycated
Glycosylation
62 – 62
N-linked (Glc) (glycation) lysine
Literature citations
Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation.
Adams J.G. III; Winter W.P.; Rucknagel D.L.; Spencer H.H.;
Science 176:1427-1429(1972)
Cited for: VARIANT ANN ARBOR ARG-81;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.