Variant position: 81 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKVADALTNAVAHVDDMPNA LSALSDLHAHKLRVDPVNFKL
Gorilla KKVADALTNAVAHVDDMPNA LSALSDLHAHKLRVDPVNFKL
Rhesus macaque KKVADALTLAVGHVDDMPNA LSALSDLHAHKLRVDPVNFKL
Chimpanzee KKVADALTNAVAHVDDMPNA LSALSDLHAHKLRVDPVNFKL
Mouse KKVADALASAAGHLDDLPGA LSALSDLHAHKLRVDPVNFKL
Rat KKVADALAKAADHVEDLPGA LSTLSDLHAHKLRVDPVNFKF
Pig QKVADALTKAVGHLDDLPGA LSALSDLHAHKLRVDPVNFKL
Bovine AKVAAALTKAVEHLDDLPGA LSELSDLHAHKLRVDPVNFKL
Rabbit KKVSEALTKAVGHLDDLPGA LSTLSDLHAHKLRVDPVNFKL
Sheep EKVAAALTKAVGHLDDLPGT LSDLSDLHAHKLRVDPVNFKL
Cat QKVADALTQAVAHMDDLPTA MSALSDLHAYKLRVDPVNFKF
Horse KKVGDALTLAVGHLDDLPGA LSNLSDLHAHKLRVDPVNFKL
Chicken KKVVAALIEAANHIDDIAGT LSKLSDLHAHKLRVDPVNFKL
Xenopus tropicalis KKVSDALNEACNHLDNIAGC LSKLSDLHAYDLRVDPGNFPL
Zebrafish KTIMGAVGEAISKIDDLVGG LAALSELHAFKLRVDPANFKI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
88 – 88 Iron (heme proximal ligand)
61 – 61 Not glycated
91 – 91 Not glycated
100 – 100 Not glycated
62 – 62 N-linked (Glc) (glycation) lysine
Biosynthesis of hemoglobin Ann Arbor: evidence for catabolic and feedback regulation.
Adams J.G. III; Winter W.P.; Rucknagel D.L.; Spencer H.H.;
Cited for: VARIANT ANN ARBOR ARG-81;
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