Variant position: 85 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DALTNAVAHVDDMPNALSAL SDLHAHKLRVDPVNFKLLSHC
Gorilla DALTNAVAHVDDMPNALSAL SDLHAHKLRVDPVNFKLLSHC
Rhesus macaque DALTLAVGHVDDMPNALSAL SDLHAHKLRVDPVNFKLLSHC
Chimpanzee DALTNAVAHVDDMPNALSAL SDLHAHKLRVDPVNFKLLSHC
Mouse DALASAAGHLDDLPGALSAL SDLHAHKLRVDPVNFKLLSHC
Rat DALAKAADHVEDLPGALSTL SDLHAHKLRVDPVNFKFLSHC
Pig DALTKAVGHLDDLPGALSAL SDLHAHKLRVDPVNFKLLSHC
Bovine AALTKAVEHLDDLPGALSEL SDLHAHKLRVDPVNFKLLSHS
Rabbit EALTKAVGHLDDLPGALSTL SDLHAHKLRVDPVNFKLLSHC
Sheep AALTKAVGHLDDLPGTLSDL SDLHAHKLRVDPVNFKLLSHS
Cat DALTQAVAHMDDLPTAMSAL SDLHAYKLRVDPVNFKFLSHC
Horse DALTLAVGHLDDLPGALSNL SDLHAHKLRVDPVNFKLLSHC
Chicken AALIEAANHIDDIAGTLSKL SDLHAHKLRVDPVNFKLLGQC
Xenopus tropicalis DALNEACNHLDNIAGCLSKL SDLHAYDLRVDPGNFPLLAHQ
Zebrafish GAVGEAISKIDDLVGGLAAL SELHAFKLRVDPANFKILSHN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Hb Etobicoke, alpha 85(F5) Ser leads to Arg found in a newborn of French-Indian-English descent.
Headlee M.G.; Nakatsuji T.; Lam H.; Wrightstone R.N.; Huisman T.H.;
Cited for: VARIANT ETOBICOKE ARG-85;
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