Variant position: 86 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ALTNAVAHVDDMPNALSALS DLHAHKLRVDPVNFKLLSHCL
Gorilla ALTNAVAHVDDMPNALSALS DLHAHKLRVDPVNFKLLSHCL
Rhesus macaque ALTLAVGHVDDMPNALSALS DLHAHKLRVDPVNFKLLSHCL
Chimpanzee ALTNAVAHVDDMPNALSALS DLHAHKLRVDPVNFKLLSHCL
Mouse ALASAAGHLDDLPGALSALS DLHAHKLRVDPVNFKLLSHCL
Rat ALAKAADHVEDLPGALSTLS DLHAHKLRVDPVNFKFLSHCL
Pig ALTKAVGHLDDLPGALSALS DLHAHKLRVDPVNFKLLSHCL
Bovine ALTKAVEHLDDLPGALSELS DLHAHKLRVDPVNFKLLSHSL
Rabbit ALTKAVGHLDDLPGALSTLS DLHAHKLRVDPVNFKLLSHCL
Sheep ALTKAVGHLDDLPGTLSDLS DLHAHKLRVDPVNFKLLSHSL
Cat ALTQAVAHMDDLPTAMSALS DLHAYKLRVDPVNFKFLSHCL
Horse ALTLAVGHLDDLPGALSNLS DLHAHKLRVDPVNFKLLSHCL
Chicken ALIEAANHIDDIAGTLSKLS DLHAHKLRVDPVNFKLLGQCF
Xenopus tropicalis ALNEACNHLDNIAGCLSKLS DLHAYDLRVDPGNFPLLAHQI
Zebrafish AVGEAISKIDDLVGGLAALS ELHAFKLRVDPANFKILSHNV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Haemoglobin Inkster (alpha2 85aspartic acid leads to valine beta2) coexisting with beta-thalassaemia in a Caucasian family.
Reed R.E.; Winter W.P.; Rucknagel D.L.;
Br. J. Haematol. 26:475-484(1974)
Cited for: VARIANT INKSTER VAL-86;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.