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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.Asp86Tyr

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 86 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Aspartate (D) to Tyrosine (Y) at position 86 (D86Y, p.Asp86Tyr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and acidic (D) to large size and aromatic (Y) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In Atago; O(2) affinity up. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 86 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help ALTNAVAHVDDMPNALSALS D LHAHKLRVDPVNFKLLSHCL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         ALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCL

Gorilla                       ALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCL

                              ALTTAVAHLDDLPGALSALSDLHAYKLRVDPVNFKLLSHCL

Rhesus macaque                ALTLAVGHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCL

Chimpanzee                    ALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCL

Mouse                         ALASAAGHLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCL

Rat                           ALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCL

Pig                           ALTKAVGHLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCL

Bovine                        ALTKAVEHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSL

Rabbit                        ALTKAVGHLDDLPGALSTLSDLHAHKLRVDPVNFKLLSHCL

Sheep                         ALTKAVGHLDDLPGTLSDLSDLHAHKLRVDPVNFKLLSHSL

Cat                           ALTQAVAHMDDLPTAMSALSDLHAYKLRVDPVNFKFLSHCL

Horse                         ALTLAVGHLDDLPGALSNLSDLHAHKLRVDPVNFKLLSHCL

Chicken                       ALIEAANHIDDIAGTLSKLSDLHAHKLRVDPVNFKLLGQCF

Xenopus tropicalis            ALNEACNHLDNIAGCLSKLSDLHAYDLRVDPGNFPLLAHQI

Zebrafish                     AVGEAISKIDDLVGGLAALSELHAFKLRVDPANFKILSHNV

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Domain 2 – 142 Globin
Binding site 88 – 88 proximal binding residue
Site 91 – 91 Not glycated
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Helix 82 – 90



Literature citations
Hemoglobin Atago (alpha2-85 Tyr beta-2) a new abnormal human hemoglobin found in Nagasaki. Biochemical studies on hemoglobins and myoglobins. VI.
Fujiwara N.; Maekawa T.; Matsuda G.;
Int. J. Protein Res. 3:35-39(1971)
Cited for: VARIANT ATAGO TYR-86;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.