Sequence information
Variant position: 88 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
TNAVAHVDDMPNALSALSDL
H AHKLRVDPVNFKLLSHCLLV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TNAVAHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLV
Gorilla TNAVAHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLV
TTAVAHLDDLPGALSALSDLH AYKLRVDPVNFKLLSHCLLV
Rhesus macaque TLAVGHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLV
Chimpanzee TNAVAHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLV
Mouse ASAAGHLDDLPGALSALSDLH AHKLRVDPVNFKLLSHCLLV
Rat AKAADHVEDLPGALSTLSDLH AHKLRVDPVNFKFLSHCLLV
Pig TKAVGHLDDLPGALSALSDLH AHKLRVDPVNFKLLSHCLLV
Bovine TKAVEHLDDLPGALSELSDLH AHKLRVDPVNFKLLSHSLLV
Rabbit TKAVGHLDDLPGALSTLSDLH AHKLRVDPVNFKLLSHCLLV
Sheep TKAVGHLDDLPGTLSDLSDLH AHKLRVDPVNFKLLSHSLLV
Cat TQAVAHMDDLPTAMSALSDLH AYKLRVDPVNFKFLSHCLLV
Horse TLAVGHLDDLPGALSNLSDLH AHKLRVDPVNFKLLSHCLLS
Chicken IEAANHIDDIAGTLSKLSDLH AHKLRVDPVNFKLLGQCFLV
Xenopus tropicalis NEACNHLDNIAGCLSKLSDLH AYDLRVDPGNFPLLAHQILV
Zebrafish GEAISKIDDLVGGLAALSELH AFKLRVDPANFKILSHNVIV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
Hb Auckland [alpha 87(F8) His-->Asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry.
Brennan S.O.; Matthews J.R.;
Hemoglobin 21:393-403(1997)
Cited for: VARIANT AUCKLAND ASN-88;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.