Variant position: 88 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TNAVAHVDDMPNALSALSDL HAHKLRVDPVNFKLLSHCLLV
Gorilla TNAVAHVDDMPNALSALSDL HAHKLRVDPVNFKLLSHCLLV
Rhesus macaque TLAVGHVDDMPNALSALSDL HAHKLRVDPVNFKLLSHCLLV
Chimpanzee TNAVAHVDDMPNALSALSDL HAHKLRVDPVNFKLLSHCLLV
Mouse ASAAGHLDDLPGALSALSDL HAHKLRVDPVNFKLLSHCLLV
Rat AKAADHVEDLPGALSTLSDL HAHKLRVDPVNFKFLSHCLLV
Pig TKAVGHLDDLPGALSALSDL HAHKLRVDPVNFKLLSHCLLV
Bovine TKAVEHLDDLPGALSELSDL HAHKLRVDPVNFKLLSHSLLV
Rabbit TKAVGHLDDLPGALSTLSDL HAHKLRVDPVNFKLLSHCLLV
Sheep TKAVGHLDDLPGTLSDLSDL HAHKLRVDPVNFKLLSHSLLV
Cat TQAVAHMDDLPTAMSALSDL HAYKLRVDPVNFKFLSHCLLV
Horse TLAVGHLDDLPGALSNLSDL HAHKLRVDPVNFKLLSHCLLS
Chicken IEAANHIDDIAGTLSKLSDL HAHKLRVDPVNFKLLGQCFLV
Xenopus tropicalis NEACNHLDNIAGCLSKLSDL HAYDLRVDPGNFPLLAHQILV
Zebrafish GEAISKIDDLVGGLAALSEL HAFKLRVDPANFKILSHNVIV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
A case of hemoglobin Iwata [alpha 87(F8)His leads to Arg] in China.
Liu G.Y.; Zhang G.X.; Nie S.Y.; Luo H.Y.; Teng Y.Q.; Liu S.P.; Song M.; Son L.; Chen S.S.; Jia P.C.; Liang C.C.;
Cited for: VARIANT IWATA ARG-88;
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