Variant position: 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NAVAHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLVT
Gorilla NAVAHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLVT
Rhesus macaque LAVGHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLVT
Chimpanzee NAVAHVDDMPNALSALSDLH AHKLRVDPVNFKLLSHCLLVT
Mouse SAAGHLDDLPGALSALSDLH AHKLRVDPVNFKLLSHCLLVT
Rat KAADHVEDLPGALSTLSDLH AHKLRVDPVNFKFLSHCLLVT
Pig KAVGHLDDLPGALSALSDLH AHKLRVDPVNFKLLSHCLLVT
Bovine KAVEHLDDLPGALSELSDLH AHKLRVDPVNFKLLSHSLLVT
Rabbit KAVGHLDDLPGALSTLSDLH AHKLRVDPVNFKLLSHCLLVT
Sheep KAVGHLDDLPGTLSDLSDLH AHKLRVDPVNFKLLSHSLLVT
Cat QAVAHMDDLPTAMSALSDLH AYKLRVDPVNFKFLSHCLLVT
Horse LAVGHLDDLPGALSNLSDLH AHKLRVDPVNFKLLSHCLLST
Chicken EAANHIDDIAGTLSKLSDLH AHKLRVDPVNFKLLGQCFLVV
Xenopus tropicalis EACNHLDNIAGCLSKLSDLH AYDLRVDPGNFPLLAHQILVV
Zebrafish EAISKIDDLVGGLAALSELH AFKLRVDPANFKILSHNVIVV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Increased oxygen affinity with normal heterotropic effects in hemoglobin Loire [alpha 88(F9)Ala----Ser].
Baklouti F.; Baudin-Chich V.; Kister J.; Marden M.; Teyssier G.; Poyart C.; Delaunay J.; Wajcman H.;
Eur. J. Biochem. 177:307-312(1988)
Cited for: VARIANT LOIRE SER-89;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.