Sequence information
Variant position: 91 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
VAHVDDMPNALSALSDLHAH
K LRVDPVNFKLLSHCLLVTLA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VAHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLA
Gorilla VAHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLA
VAHLDDLPGALSALSDLHAYK LRVDPVNFKLLSHCLLVTLA
Rhesus macaque VGHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLA
Chimpanzee VAHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLA
Mouse AGHLDDLPGALSALSDLHAHK LRVDPVNFKLLSHCLLVTLA
Rat ADHVEDLPGALSTLSDLHAHK LRVDPVNFKFLSHCLLVTLA
Pig VGHLDDLPGALSALSDLHAHK LRVDPVNFKLLSHCLLVTLA
Bovine VEHLDDLPGALSELSDLHAHK LRVDPVNFKLLSHSLLVTLA
Rabbit VGHLDDLPGALSTLSDLHAHK LRVDPVNFKLLSHCLLVTLA
Sheep VGHLDDLPGTLSDLSDLHAHK LRVDPVNFKLLSHSLLVTLA
Cat VAHMDDLPTAMSALSDLHAYK LRVDPVNFKFLSHCLLVTLA
Horse VGHLDDLPGALSNLSDLHAHK LRVDPVNFKLLSHCLLSTLA
Chicken ANHIDDIAGTLSKLSDLHAHK LRVDPVNFKLLGQCFLVVVA
Xenopus tropicalis CNHLDNIAGCLSKLSDLHAYD LRVDPGNFPLLAHQILVVVA
Zebrafish ISKIDDLVGGLAALSELHAFK LRVDPANFKILSHNVIVVIA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
HB Handa [alpha 90 (FG 2) Lys replaced by Met]: structure and biosynthesis of a new slightly higher oxygen affinity variant.
Harano T.; Harano K.; Shibata S.; Ueda S.; Imai K.; Seki M.;
Hemoglobin 6:379-389(1982)
Cited for: VARIANT HANDA MET-91;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.