Home  |  Contact

UniProtKB/Swiss-Prot P69905: Variant p.Leu92Pro

Hemoglobin subunit alpha
Gene: HBA2
Variant information

Variant position:  92
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Leucine (L) to Proline (P) at position 92 (L92P, p.Leu92Pro).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are medium size and hydrophobic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In Port Phillip; unstable.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  92
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  142
The length of the canonical sequence.

Location on the sequence:   AHVDDMPNALSALSDLHAHK  L RVDPVNFKLLSHCLLVTLAA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         AHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAA

Gorilla                       AHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAA

                              AHLDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLAC

Rhesus macaque                GHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAA

Chimpanzee                    AHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAA

Mouse                         GHLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAS

Rat                           DHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLAC

Pig                           GHLDDLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAA

Bovine                        EHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLAS

Rabbit                        GHLDDLPGALSTLSDLHAHKLRVDPVNFKLLSHCLLVTLAN

Sheep                         GHLDDLPGTLSDLSDLHAHKLRVDPVNFKLLSHSLLVTLAC

Cat                           AHMDDLPTAMSALSDLHAYKLRVDPVNFKFLSHCLLVTLAC

Horse                         GHLDDLPGALSNLSDLHAHKLRVDPVNFKLLSHCLLSTLAV

Chicken                       NHIDDIAGTLSKLSDLHAHKLRVDPVNFKLLGQCFLVVVAI

Xenopus tropicalis            NHLDNIAGCLSKLSDLHAYDLRVDPGNFPLLAHQILVVVAI

Zebrafish                     SKIDDLVGGLAALSELHAFKLRVDPANFKILSHNVIVVIAM

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Metal binding 88 – 88 Iron (heme proximal ligand)
Site 91 – 91 Not glycated
Site 92 – 93 (Microbial infection) Cleavage; by N.americanus apr-2
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Modified residue 109 – 109 Phosphothreonine
Turn 91 – 93


Literature citations

Haemoglobin Port Phillip alpha91 (FG3) Leu replaced by Pro, a new unstable haemoglobin.
Brennan S.O.; Tauro G.P.; Melrose W.;
FEBS Lett. 81:115-117(1977)
Cited for: VARIANT PORT PHILLIP PRO-92;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.