Variant position: 92 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLAA
Gorilla AHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLAA
Rhesus macaque GHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLAA
Chimpanzee AHVDDMPNALSALSDLHAHK LRVDPVNFKLLSHCLLVTLAA
Mouse GHLDDLPGALSALSDLHAHK LRVDPVNFKLLSHCLLVTLAS
Rat DHVEDLPGALSTLSDLHAHK LRVDPVNFKFLSHCLLVTLAC
Pig GHLDDLPGALSALSDLHAHK LRVDPVNFKLLSHCLLVTLAA
Bovine EHLDDLPGALSELSDLHAHK LRVDPVNFKLLSHSLLVTLAS
Rabbit GHLDDLPGALSTLSDLHAHK LRVDPVNFKLLSHCLLVTLAN
Sheep GHLDDLPGTLSDLSDLHAHK LRVDPVNFKLLSHSLLVTLAC
Cat AHMDDLPTAMSALSDLHAYK LRVDPVNFKFLSHCLLVTLAC
Horse GHLDDLPGALSNLSDLHAHK LRVDPVNFKLLSHCLLSTLAV
Chicken NHIDDIAGTLSKLSDLHAHK LRVDPVNFKLLGQCFLVVVAI
Xenopus tropicalis NHLDNIAGCLSKLSDLHAYD LRVDPGNFPLLAHQILVVVAI
Zebrafish SKIDDLVGGLAALSELHAFK LRVDPANFKILSHNVIVVIAM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
88 – 88 Iron (heme b proximal ligand)
91 – 91 Not glycated
92 – 93 (Microbial infection) Cleavage; by N.americanus apr-2
100 – 100 Not glycated
103 – 103 Phosphoserine
109 – 109 Phosphothreonine
91 – 93
Haemoglobin Port Phillip alpha91 (FG3) Leu replaced by Pro, a new unstable haemoglobin.
Brennan S.O.; Tauro G.P.; Melrose W.;
FEBS Lett. 81:115-117(1977)
Cited for: VARIANT PORT PHILLIP PRO-92;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.