Sequence information
Variant position: 92 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
AHVDDMPNALSALSDLHAHK
L RVDPVNFKLLSHCLLVTLAA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AHVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAA
Gorilla AHVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAA
AHLDDLPGALSALSDLHAYKL RVDPVNFKLLSHCLLVTLAC
Rhesus macaque GHVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAA
Chimpanzee AHVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAA
Mouse GHLDDLPGALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAS
Rat DHVEDLPGALSTLSDLHAHKL RVDPVNFKFLSHCLLVTLAC
Pig GHLDDLPGALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAA
Bovine EHLDDLPGALSELSDLHAHKL RVDPVNFKLLSHSLLVTLAS
Rabbit GHLDDLPGALSTLSDLHAHKL RVDPVNFKLLSHCLLVTLAN
Sheep GHLDDLPGTLSDLSDLHAHKL RVDPVNFKLLSHSLLVTLAC
Cat AHMDDLPTAMSALSDLHAYKL RVDPVNFKFLSHCLLVTLAC
Horse GHLDDLPGALSNLSDLHAHKL RVDPVNFKLLSHCLLSTLAV
Chicken NHIDDIAGTLSKLSDLHAHKL RVDPVNFKLLGQCFLVVVAI
Xenopus tropicalis NHLDNIAGCLSKLSDLHAYDL RVDPGNFPLLAHQILVVVAI
Zebrafish SKIDDLVGGLAALSELHAFKL RVDPANFKILSHNVIVVIAM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
88 – 88
Iron (heme b proximal ligand)
Site
91 – 91
Not glycated
Site
92 – 93
(Microbial infection) Cleavage; by N.americanus apr-2
Site
100 – 100
Not glycated
Modified residue
103 – 103
Phosphoserine
Modified residue
109 – 109
Phosphothreonine
Turn
91 – 93
Literature citations
Haemoglobin Port Phillip alpha91 (FG3) Leu replaced by Pro, a new unstable haemoglobin.
Brennan S.O.; Tauro G.P.; Melrose W.;
FEBS Lett. 81:115-117(1977)
Cited for: VARIANT PORT PHILLIP PRO-92;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.