Variant position: 93 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAAH
Gorilla HVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAAH
Rhesus macaque HVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAAH
Chimpanzee HVDDMPNALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAAH
Mouse HLDDLPGALSALSDLHAHKL RVDPVNFKLLSHCLLVTLASH
Rat HVEDLPGALSTLSDLHAHKL RVDPVNFKFLSHCLLVTLACH
Pig HLDDLPGALSALSDLHAHKL RVDPVNFKLLSHCLLVTLAAH
Bovine HLDDLPGALSELSDLHAHKL RVDPVNFKLLSHSLLVTLASH
Rabbit HLDDLPGALSTLSDLHAHKL RVDPVNFKLLSHCLLVTLANH
Sheep HLDDLPGTLSDLSDLHAHKL RVDPVNFKLLSHSLLVTLACH
Cat HMDDLPTAMSALSDLHAYKL RVDPVNFKFLSHCLLVTLACH
Horse HLDDLPGALSNLSDLHAHKL RVDPVNFKLLSHCLLSTLAVH
Chicken HIDDIAGTLSKLSDLHAHKL RVDPVNFKLLGQCFLVVVAIH
Xenopus tropicalis HLDNIAGCLSKLSDLHAYDL RVDPGNFPLLAHQILVVVAIH
Zebrafish KIDDLVGGLAALSELHAFKL RVDPANFKILSHNVIVVIAML
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
88 – 88 Iron (heme proximal ligand)
91 – 91 Not glycated
92 – 93 (Microbial infection) Cleavage; by N.americanus apr-2
100 – 100 Not glycated
103 – 103 Phosphoserine
109 – 109 Phosphothreonine
91 – 93
Hemoglobin J Cape Town-alpha-2 92 arginine replaced by glutamine beta-2.
Botha M.C.; Beale D.; Isaacs W.A.; Lehmann H.;
Cited for: VARIANT J-CAPE TOWN GLN-93;
Ligand binding in hemoglobin J Capetown.
Nagel R.L.; Gibson Q.H.; Jenkins T.;
J. Mol. Biol. 58:643-650(1971)
Cited for: CHARACTERIZATION OF VARIANT J-CAPE TOWN GLN-93;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.