Variant position: 95 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DDMPNALSALSDLHAHKLRV DPVNFKLLSHCLLVTLAAHLP
Gorilla DDMPNALSALSDLHAHKLRV DPVNFKLLSHCLLVTLAAHLP
Rhesus macaque DDMPNALSALSDLHAHKLRV DPVNFKLLSHCLLVTLAAHLP
Chimpanzee DDMPNALSALSDLHAHKLRV DPVNFKLLSHCLLVTLAAHLP
Mouse DDLPGALSALSDLHAHKLRV DPVNFKLLSHCLLVTLASHHP
Rat EDLPGALSTLSDLHAHKLRV DPVNFKFLSHCLLVTLACHHP
Pig DDLPGALSALSDLHAHKLRV DPVNFKLLSHCLLVTLAAHHP
Bovine DDLPGALSELSDLHAHKLRV DPVNFKLLSHSLLVTLASHLP
Rabbit DDLPGALSTLSDLHAHKLRV DPVNFKLLSHCLLVTLANHHP
Sheep DDLPGTLSDLSDLHAHKLRV DPVNFKLLSHSLLVTLACHLP
Cat DDLPTAMSALSDLHAYKLRV DPVNFKFLSHCLLVTLACHHP
Horse DDLPGALSNLSDLHAHKLRV DPVNFKLLSHCLLSTLAVHLP
Chicken DDIAGTLSKLSDLHAHKLRV DPVNFKLLGQCFLVVVAIHHP
Xenopus tropicalis DNIAGCLSKLSDLHAYDLRV DPGNFPLLAHQILVVVAIHFP
Zebrafish DDLVGGLAALSELHAFKLRV DPANFKILSHNVIVVIAMLFP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
88 – 88 Iron (heme proximal ligand)
91 – 91 Not glycated
100 – 100 Not glycated
103 – 103 Phosphoserine
109 – 109 Phosphothreonine
Hb Setif: G1 (94) Asp-Tyr. A new chain hemoglobin variant with substitution of the residue involved in hydrogen bond between unlike subunits.
Wajcman H.; Belkhodja O.; Labie D.;
FEBS Lett. 27:298-300(1972)
Cited for: VARIANT SETIF TYR-95;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.