Sequence information
Variant position: 96 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
DMPNALSALSDLHAHKLRVD
P VNFKLLSHCLLVTLAAHLPA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DMPNALSALSDLHAHKLRVDP VNFKLLSHCLLVTLAAHLPA
Gorilla DMPNALSALSDLHAHKLRVDP VNFKLLSHCLLVTLAAHLPA
DLPGALSALSDLHAYKLRVDP VNFKLLSHCLLVTLACHHPT
Rhesus macaque DMPNALSALSDLHAHKLRVDP VNFKLLSHCLLVTLAAHLPA
Chimpanzee DMPNALSALSDLHAHKLRVDP VNFKLLSHCLLVTLAAHLPA
Mouse DLPGALSALSDLHAHKLRVDP VNFKLLSHCLLVTLASHHPA
Rat DLPGALSTLSDLHAHKLRVDP VNFKFLSHCLLVTLACHHPG
Pig DLPGALSALSDLHAHKLRVDP VNFKLLSHCLLVTLAAHHPD
Bovine DLPGALSELSDLHAHKLRVDP VNFKLLSHSLLVTLASHLPS
Rabbit DLPGALSTLSDLHAHKLRVDP VNFKLLSHCLLVTLANHHPS
Sheep DLPGTLSDLSDLHAHKLRVDP VNFKLLSHSLLVTLACHLPN
Cat DLPTAMSALSDLHAYKLRVDP VNFKFLSHCLLVTLACHHPA
Horse DLPGALSNLSDLHAHKLRVDP VNFKLLSHCLLSTLAVHLPN
Chicken DIAGTLSKLSDLHAHKLRVDP VNFKLLGQCFLVVVAIHHPA
Xenopus tropicalis NIAGCLSKLSDLHAYDLRVDP GNFPLLAHQILVVVAIHFPK
Zebrafish DLVGGLAALSELHAFKLRVDP ANFKILSHNVIVVIAMLFPA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Metal binding
88 – 88
Iron (heme b proximal ligand)
Site
91 – 91
Not glycated
Site
100 – 100
Not glycated
Modified residue
103 – 103
Phosphoserine
Modified residue
109 – 109
Phosphothreonine
Literature citations
Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin.
Wajcman H.; Kister J.; Riou J.; Galacteros F.; Girot R.; Maier-Redelsperger M.; Nayudu N.V.S.; Giordano P.C.;
Hemoglobin 22:11-22(1998)
Cited for: VARIANT GODAVARI THR-96;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.