Variant position: 110 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HKLRVDPVNFKLLSHCLLVT LAAHLPAEFTPAVHASLDKFL
Gorilla HKLRVDPVNFKLLSHCLLVT LAAHLPAEFTPAVHASLDKFL
Rhesus macaque HKLRVDPVNFKLLSHCLLVT LAAHLPAEFTPAVHASLDKFL
Chimpanzee HKLRVDPVNFKLLSHCLLVT LAAHLPAEFTPAVHASLDKFL
Mouse HKLRVDPVNFKLLSHCLLVT LASHHPADFTPAVHASLDKFL
Rat HKLRVDPVNFKFLSHCLLVT LACHHPGDFTPAMHASLDKFL
Pig HKLRVDPVNFKLLSHCLLVT LAAHHPDDFNPSVHASLDKFL
Bovine HKLRVDPVNFKLLSHSLLVT LASHLPSDFTPAVHASLDKFL
Rabbit HKLRVDPVNFKLLSHCLLVT LANHHPSEFTPAVHASLDKFL
Sheep HKLRVDPVNFKLLSHSLLVT LACHLPNDFTPAVHASLDKFL
Cat YKLRVDPVNFKFLSHCLLVT LACHHPAEFTPAVHASLDKFF
Horse HKLRVDPVNFKLLSHCLLST LAVHLPNDFTPAVHASLDKFL
Chicken HKLRVDPVNFKLLGQCFLVV VAIHHPAALTPEVHASLDKFL
Xenopus tropicalis YDLRVDPGNFPLLAHQILVV VAIHFPKQFDPATHKALDKFL
Zebrafish FKLRVDPANFKILSHNVIVV IAMLFPADFTPEVHVSVDKFF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Hemoglobin Suan-Dok (alpha 2 109 (G16) Leu replaced by Arg beta 2): an unstable variant associated with alpha-thalassemia.
Sanguansermsri T.; Matragoon S.; Changloah L.; Flatz G.;
Cited for: VARIANT SUAN-DOK ARG-110;
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