Variant position: 113 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RVDPVNFKLLSHCLLVTLAA HLPAEFTPAVHASLDKFLASV
Gorilla RVDPVNFKLLSHCLLVTLAA HLPAEFTPAVHASLDKFLASV
Rhesus macaque RVDPVNFKLLSHCLLVTLAA HLPAEFTPAVHASLDKFLASV
Chimpanzee RVDPVNFKLLSHCLLVTLAA HLPAEFTPAVHASLDKFLASV
Mouse RVDPVNFKLLSHCLLVTLAS HHPADFTPAVHASLDKFLASV
Rat RVDPVNFKFLSHCLLVTLAC HHPGDFTPAMHASLDKFLASV
Pig RVDPVNFKLLSHCLLVTLAA HHPDDFNPSVHASLDKFLANV
Bovine RVDPVNFKLLSHSLLVTLAS HLPSDFTPAVHASLDKFLANV
Rabbit RVDPVNFKLLSHCLLVTLAN HHPSEFTPAVHASLDKFLANV
Sheep RVDPVNFKLLSHSLLVTLAC HLPNDFTPAVHASLDKFLANV
Cat RVDPVNFKFLSHCLLVTLAC HHPAEFTPAVHASLDKFFSAV
Horse RVDPVNFKLLSHCLLSTLAV HLPNDFTPAVHASLDKFLSSV
Chicken RVDPVNFKLLGQCFLVVVAI HHPAALTPEVHASLDKFLCAV
Xenopus tropicalis RVDPGNFPLLAHQILVVVAI HFPKQFDPATHKALDKFLVSV
Zebrafish RVDPANFKILSHNVIVVIAM LFPADFTPEVHVSVDKFFNNL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Clinical studies and physiological properties of Hopkins-2 haemoglobin.
Charache S.; Ostertag W.; von Ehrenstein G.;
Nature New Biol. 234:248-251(1971)
Cited for: VARIANT HOPKINS-II ASP-113;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.