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UniProtKB/Swiss-Prot P69905: Variant p.Pro115Arg

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 115 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Proline (P) to Arginine (R) at position 115 (P115R, p.Pro115Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (P) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In Chiapas. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 115 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help DPVNFKLLSHCLLVTLAAHL P AEFTPAVHASLDKFLASVST The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         DPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVST

Gorilla                       DPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVST

                              DPVNFKLLSHCLLVTLACHHPTEFTPAVHASLDKFFAAVST

Rhesus macaque                DPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVST

Chimpanzee                    DPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVST

Mouse                         DPVNFKLLSHCLLVTLASHHPADFTPAVHASLDKFLASVST

Rat                           DPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVST

Pig                           DPVNFKLLSHCLLVTLAAHHPDDFNPSVHASLDKFLANVST

Bovine                        DPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVST

Rabbit                        DPVNFKLLSHCLLVTLANHHPSEFTPAVHASLDKFLANVST

Sheep                         DPVNFKLLSHSLLVTLACHLPNDFTPAVHASLDKFLANVST

Cat                           DPVNFKFLSHCLLVTLACHHPAEFTPAVHASLDKFFSAVST

Horse                         DPVNFKLLSHCLLSTLAVHLPNDFTPAVHASLDKFLSSVST

Chicken                       DPVNFKLLGQCFLVVVAIHHPAALTPEVHASLDKFLCAVGT

Xenopus tropicalis            DPGNFPLLAHQILVVVAIHFPKQFDPATHKALDKFLVSVSN

Zebrafish                     DPANFKILSHNVIVVIAMLFPADFTPEVHVSVDKFFNNLAL

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Domain 2 – 142 Globin
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Modified residue 109 – 109 Phosphothreonine
Modified residue 125 – 125 Phosphoserine
Modified residue 132 – 132 Phosphoserine
Modified residue 135 – 135 Phosphothreonine
Turn 115 – 117



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.