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UniProtKB/Swiss-Prot P69905: Variant p.Glu117Ala

Hemoglobin subunit alpha
Gene: HBA2
Variant information

Variant position:  117
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Glutamate (E) to Alanine (A) at position 117 (E117A, p.Glu117Ala).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (E) to small size and hydrophobic (A)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In Ube-4.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  117
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  142
The length of the canonical sequence.

Location on the sequence:   VNFKLLSHCLLVTLAAHLPA  E FTPAVHASLDKFLASVSTVL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         VNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVL

Gorilla                       VNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVL

                              VNFKLLSHCLLVTLACHHPTEFTPAVHASLDKFFAAVSTVL

Rhesus macaque                VNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVL

Chimpanzee                    VNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVL

Mouse                         VNFKLLSHCLLVTLASHHPADFTPAVHASLDKFLASVSTVL

Rat                           VNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVL

Pig                           VNFKLLSHCLLVTLAAHHPDDFNPSVHASLDKFLANVSTVL

Bovine                        VNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVSTVL

Rabbit                        VNFKLLSHCLLVTLANHHPSEFTPAVHASLDKFLANVSTVL

Sheep                         VNFKLLSHSLLVTLACHLPNDFTPAVHASLDKFLANVSTVL

Cat                           VNFKFLSHCLLVTLACHHPAEFTPAVHASLDKFFSAVSTVL

Horse                         VNFKLLSHCLLSTLAVHLPNDFTPAVHASLDKFLSSVSTVL

Chicken                       VNFKLLGQCFLVVVAIHHPAALTPEVHASLDKFLCAVGTVL

Xenopus tropicalis            GNFPLLAHQILVVVAIHFPKQFDPATHKALDKFLVSVSNVL

Zebrafish                     ANFKILSHNVIVVIAMLFPADFTPEVHVSVDKFFNNLALAL

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Modified residue 109 – 109 Phosphothreonine
Modified residue 125 – 125 Phosphoserine
Modified residue 132 – 132 Phosphoserine
Modified residue 135 – 135 Phosphothreonine
Turn 115 – 117


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.