Sequence information
Variant position: 122 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
LSHCLLVTLAAHLPAEFTPA
V HASLDKFLASVSTVLTSKYR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSHCLLVTLAAHLPAEFTPAV HASLDKFLASVSTVLTSKYR
Gorilla LSHCLLVTLAAHLPAEFTPAV HASLDKFLASVSTVLTSKYR
LSHCLLVTLACHHPTEFTPAV HASLDKFFAAVSTVLTSKYR
Rhesus macaque LSHCLLVTLAAHLPAEFTPAV HASLDKFLASVSTVLTSKYR
Chimpanzee LSHCLLVTLAAHLPAEFTPAV HASLDKFLASVSTVLTSKYR
Mouse LSHCLLVTLASHHPADFTPAV HASLDKFLASVSTVLTSKYR
Rat LSHCLLVTLACHHPGDFTPAM HASLDKFLASVSTVLTSKYR
Pig LSHCLLVTLAAHHPDDFNPSV HASLDKFLANVSTVLTSKYR
Bovine LSHSLLVTLASHLPSDFTPAV HASLDKFLANVSTVLTSKYR
Rabbit LSHCLLVTLANHHPSEFTPAV HASLDKFLANVSTVLTSKYR
Sheep LSHSLLVTLACHLPNDFTPAV HASLDKFLANVSTVLTSKYR
Cat LSHCLLVTLACHHPAEFTPAV HASLDKFFSAVSTVLTSKYR
Horse LSHCLLSTLAVHLPNDFTPAV HASLDKFLSSVSTVLTSKYR
Chicken LGQCFLVVVAIHHPAALTPEV HASLDKFLCAVGTVLTAKYR
Xenopus tropicalis LAHQILVVVAIHFPKQFDPAT HKALDKFLVSVSNVLTSKYR
Zebrafish LSHNVIVVIAMLFPADFTPEV HVSVDKFFNNLALALSEKYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
2 – 142
Hemoglobin subunit alpha
Site
122 – 123
(Microbial infection) Cleavage; by N.americanus apr-2
Modified residue
103 – 103
Phosphoserine
Modified residue
109 – 109
Phosphothreonine
Modified residue
125 – 125
Phosphoserine
Modified residue
132 – 132
Phosphoserine
Modified residue
135 – 135
Phosphothreonine
Modified residue
138 – 138
Phosphothreonine
Modified residue
139 – 139
Phosphoserine
Helix
120 – 138
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.