Variant position: 122 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR
Gorilla LSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR
Rhesus macaque LSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR
Chimpanzee LSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKYR
Mouse LSHCLLVTLASHHPADFTPA VHASLDKFLASVSTVLTSKYR
Rat LSHCLLVTLACHHPGDFTPA MHASLDKFLASVSTVLTSKYR
Pig LSHCLLVTLAAHHPDDFNPS VHASLDKFLANVSTVLTSKYR
Bovine LSHSLLVTLASHLPSDFTPA VHASLDKFLANVSTVLTSKYR
Rabbit LSHCLLVTLANHHPSEFTPA VHASLDKFLANVSTVLTSKYR
Sheep LSHSLLVTLACHLPNDFTPA VHASLDKFLANVSTVLTSKYR
Cat LSHCLLVTLACHHPAEFTPA VHASLDKFFSAVSTVLTSKYR
Horse LSHCLLSTLAVHLPNDFTPA VHASLDKFLSSVSTVLTSKYR
Chicken LGQCFLVVVAIHHPAALTPE VHASLDKFLCAVGTVLTAKYR
Xenopus tropicalis LAHQILVVVAIHFPKQFDPA THKALDKFLVSVSNVLTSKYR
Zebrafish LSHNVIVVIAMLFPADFTPE VHVSVDKFFNNLALALSEKYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
122 – 123 (Microbial infection) Cleavage; by N.americanus apr-2
103 – 103 Phosphoserine
109 – 109 Phosphothreonine
125 – 125 Phosphoserine
132 – 132 Phosphoserine
135 – 135 Phosphothreonine
138 – 138 Phosphothreonine
139 – 139 Phosphoserine
120 – 138
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.