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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.Asp127Val

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 127
Type of variant: help LB/B
Residue change: help From Aspartate (D) to Valine (V) at position 127 (D127V, p.Asp127Val).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and hydrophobic (V)
BLOSUM score: help -3
Variant description: help In Fukutomi; O(2) affinity up.
Other resources: help


Sequence information Variant position: help 127
Protein sequence length: help 142
Location on the sequence: help LVTLAAHLPAEFTPAVHASL D KFLASVSTVLTSKYR
Residue conservation: help 
Human                         LVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Gorilla                       LVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

                              LVTLACHHPTEFTPAVHASLDKFFAAVSTVLTSKYR

Rhesus macaque                LVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Chimpanzee                    LVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Mouse                         LVTLASHHPADFTPAVHASLDKFLASVSTVLTSKYR

Rat                           LVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR

Pig                           LVTLAAHHPDDFNPSVHASLDKFLANVSTVLTSKYR

Bovine                        LVTLASHLPSDFTPAVHASLDKFLANVSTVLTSKYR

Rabbit                        LVTLANHHPSEFTPAVHASLDKFLANVSTVLTSKYR

Sheep                         LVTLACHLPNDFTPAVHASLDKFLANVSTVLTSKYR

Cat                           LVTLACHHPAEFTPAVHASLDKFFSAVSTVLTSKYR

Horse                         LSTLAVHLPNDFTPAVHASLDKFLSSVSTVLTSKYR

Chicken                       LVVVAIHHPAALTPEVHASLDKFLCAVGTVLTAKYR

Xenopus tropicalis            LVVVAIHFPKQFDPATHKALDKFLVSVSNVLTSKYR

Zebrafish                     IVVIAMLFPADFTPEVHVSVDKFFNNLALALSEKYR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Domain 2 – 142 Globin
Modified residue 109 – 109 Phosphothreonine
Modified residue 125 – 125 Phosphoserine
Modified residue 132 – 132 Phosphoserine
Modified residue 135 – 135 Phosphothreonine
Modified residue 138 – 138 Phosphothreonine
Modified residue 139 – 139 Phosphoserine
Helix 120 – 138



Literature citations
Hb Fukutomi [alpha 126(H9)Asp----Val]: a new hemoglobin variant with high oxygen affinity.
Hidaka K.; Iuchi I.; Kobayashi T.; Katoh K.; Yaguchi K.;
Hemoglobin 14:499-509(1990)
Cited for: VARIANT FUKUTOMI VAL-127;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.