Variant position: 131 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AAHLPAEFTPAVHASLDKFL ASVSTVLTSKYR
Gorilla AAHLPAEFTPAVHASLDKFL ASVSTVLTSKYR
Rhesus macaque AAHLPAEFTPAVHASLDKFL ASVSTVLTSKYR
Chimpanzee AAHLPAEFTPAVHASLDKFL ASVSTVLTSKYR
Mouse ASHHPADFTPAVHASLDKFL ASVSTVLTSKYR
Rat ACHHPGDFTPAMHASLDKFL ASVSTVLTSKYR
Pig AAHHPDDFNPSVHASLDKFL ANVSTVLTSKYR
Bovine ASHLPSDFTPAVHASLDKFL ANVSTVLTSKYR
Rabbit ANHHPSEFTPAVHASLDKFL ANVSTVLTSKYR
Sheep ACHLPNDFTPAVHASLDKFL ANVSTVLTSKYR
Cat ACHHPAEFTPAVHASLDKFF SAVSTVLTSKYR
Horse AVHLPNDFTPAVHASLDKFL SSVSTVLTSKYR
Chicken AIHHPAALTPEVHASLDKFL CAVGTVLTAKYR
Xenopus tropicalis AIHFPKQFDPATHKALDKFL VSVSNVLTSKYR
Zebrafish AMLFPADFTPEVHVSVDKFF NNLALALSEKYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Hb Yuda or alpha 130(H13)Ala-->Asp; a new alpha chain variant with low oxygen affinity.
Fujisawa K.; Hattori Y.; Ohba Y.; Ando S.;
Cited for: VARIANT YUDA ASP-131;
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