Variant position: 132 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AHLPAEFTPAVHASLDKFLA SVSTVLTSKYR
Gorilla AHLPAEFTPAVHASLDKFLA SVSTVLTSKYR
Rhesus macaque AHLPAEFTPAVHASLDKFLA SVSTVLTSKYR
Chimpanzee AHLPAEFTPAVHASLDKFLA SVSTVLTSKYR
Mouse SHHPADFTPAVHASLDKFLA SVSTVLTSKYR
Rat CHHPGDFTPAMHASLDKFLA SVSTVLTSKYR
Pig AHHPDDFNPSVHASLDKFLA NVSTVLTSKYR
Bovine SHLPSDFTPAVHASLDKFLA NVSTVLTSKYR
Rabbit NHHPSEFTPAVHASLDKFLA NVSTVLTSKYR
Sheep CHLPNDFTPAVHASLDKFLA NVSTVLTSKYR
Cat CHHPAEFTPAVHASLDKFFS AVSTVLTSKYR
Horse VHLPNDFTPAVHASLDKFLS SVSTVLTSKYR
Chicken IHHPAALTPEVHASLDKFLC AVGTVLTAKYR
Xenopus tropicalis IHFPKQFDPATHKALDKFLV SVSNVLTSKYR
Zebrafish MLFPADFTPEVHVSVDKFFN NLALALSEKYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio: Hb Questembert (alpha 131[H14]Ser-->Pro) and Hb Caen (alpha 132[H15]Val-->Gly).
Wajcman H.; Vasseur C.; Blouquit Y.; Rosa J.; Labie D.; Najman A.; Reman O.; Leporrier M.; Galacteros F.;
Am. J. Hematol. 42:367-374(1993)
Cited for: VARIANT QUESTEMBERT PRO-132;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.