Variant position: 134 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LPAEFTPAVHASLDKFLASV STVLTSKYR
Gorilla LPAEFTPAVHASLDKFLASV STVLTSKYR
Rhesus macaque LPAEFTPAVHASLDKFLASV STVLTSKYR
Chimpanzee LPAEFTPAVHASLDKFLASV STVLTSKYR
Mouse HPADFTPAVHASLDKFLASV STVLTSKYR
Rat HPGDFTPAMHASLDKFLASV STVLTSKYR
Pig HPDDFNPSVHASLDKFLANV STVLTSKYR
Bovine LPSDFTPAVHASLDKFLANV STVLTSKYR
Rabbit HPSEFTPAVHASLDKFLANV STVLTSKYR
Sheep LPNDFTPAVHASLDKFLANV STVLTSKYR
Cat HPAEFTPAVHASLDKFFSAV STVLTSKYR
Horse LPNDFTPAVHASLDKFLSSV STVLTSKYR
Chicken HPAALTPEVHASLDKFLCAV GTVLTAKYR
Xenopus tropicalis FPKQFDPATHKALDKFLVSV SNVLTSKYR
Zebrafish FPADFTPEVHVSVDKFFNNL ALALSEKYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
134 – 135 (Microbial infection) Cleavage; by N.americanus apr-2
125 – 125 Phosphoserine
132 – 132 Phosphoserine
135 – 135 Phosphothreonine
138 – 138 Phosphothreonine
139 – 139 Phosphoserine
120 – 138
Hb Val de Marne [alpha 133(H16)Ser-->Arg]: a new hemoglobin variant with moderate increase in oxygen affinity.
Wacjman H.; Kister J.; M'Rad A.; Marden M.C.; Riou J.; Galacteros F.;
Cited for: VARIANT VAL DE MARNE ARG-134;
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