Sequence information
Variant position: 137 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
EFTPAVHASLDKFLASVSTV
L TSKYR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EFTPAVHASLDKFLASVSTVL TSKYR
Gorilla EFTPAVHASLDKFLASVSTVL TSKYR
EFTPAVHASLDKFFAAVSTVL TSKYR
Rhesus macaque EFTPAVHASLDKFLASVSTVL TSKYR
Chimpanzee EFTPAVHASLDKFLASVSTVL TSKYR
Mouse DFTPAVHASLDKFLASVSTVL TSKYR
Rat DFTPAMHASLDKFLASVSTVL TSKYR
Pig DFNPSVHASLDKFLANVSTVL TSKYR
Bovine DFTPAVHASLDKFLANVSTVL TSKYR
Rabbit EFTPAVHASLDKFLANVSTVL TSKYR
Sheep DFTPAVHASLDKFLANVSTVL TSKYR
Cat EFTPAVHASLDKFFSAVSTVL TSKYR
Horse DFTPAVHASLDKFLSSVSTVL TSKYR
Chicken ALTPEVHASLDKFLCAVGTVL TAKYR
Xenopus tropicalis QFDPATHKALDKFLVSVSNVL TSKYR
Zebrafish DFTPEVHVSVDKFFNNLALAL SEKYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
Subunit dissociation of the unstable hemoglobin Bibba (alpha 2-136Pro(H19)beta 2).
Smith L.L.; Barton B.P.; Huisman T.H.;
J. Biol. Chem. 245:2185-2188(1970)
Cited for: VARIANT BIBBA PRO-137;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.