Variant position: 139 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TPAVHASLDKFLASVSTVLT SKYR
Gorilla TPAVHASLDKFLASVSTVLT SKYR
Rhesus macaque TPAVHASLDKFLASVSTVLT SKYR
Chimpanzee TPAVHASLDKFLASVSTVLT SKYR
Mouse TPAVHASLDKFLASVSTVLT SKYR
Rat TPAMHASLDKFLASVSTVLT SKYR
Pig NPSVHASLDKFLANVSTVLT SKYR
Bovine TPAVHASLDKFLANVSTVLT SKYR
Rabbit TPAVHASLDKFLANVSTVLT SKYR
Sheep TPAVHASLDKFLANVSTVLT SKYR
Cat TPAVHASLDKFFSAVSTVLT SKYR
Horse TPAVHASLDKFLSSVSTVLT SKYR
Chicken TPEVHASLDKFLCAVGTVLT AKYR
Xenopus tropicalis DPATHKALDKFLVSVSNVLT SKYR
Zebrafish TPEVHVSVDKFFNNLALALS EKYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Structural, functional, and subunit assembly properties of hemoglobin Attleboro [alpha 138 (H21) Ser----Pro], a variant possessing a site maturation at a critical C-terminal residue.
McDonald M.J.; Michalski L.A.; Turci S.M.; Guillette R.A.; Jue D.L.; Johnson M.H.; Moo-Penn W.F.;
Cited for: VARIANT ATTLEBORO PRO-139;
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