Sequence information
Variant position: 139 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
TPAVHASLDKFLASVSTVLT
S KYR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TPAVHASLDKFLASVSTVLTS KYR
Gorilla TPAVHASLDKFLASVSTVLTS KYR
TPAVHASLDKFFAAVSTVLTS KYR
Rhesus macaque TPAVHASLDKFLASVSTVLTS KYR
Chimpanzee TPAVHASLDKFLASVSTVLTS KYR
Mouse TPAVHASLDKFLASVSTVLTS KYR
Rat TPAMHASLDKFLASVSTVLTS KYR
Pig NPSVHASLDKFLANVSTVLTS KYR
Bovine TPAVHASLDKFLANVSTVLTS KYR
Rabbit TPAVHASLDKFLANVSTVLTS KYR
Sheep TPAVHASLDKFLANVSTVLTS KYR
Cat TPAVHASLDKFFSAVSTVLTS KYR
Horse TPAVHASLDKFLSSVSTVLTS KYR
Chicken TPEVHASLDKFLCAVGTVLTA KYR
Xenopus tropicalis DPATHKALDKFLVSVSNVLTS KYR
Zebrafish TPEVHVSVDKFFNNLALALSE KYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Literature citations
Structural, functional, and subunit assembly properties of hemoglobin Attleboro [alpha 138 (H21) Ser----Pro], a variant possessing a site maturation at a critical C-terminal residue.
McDonald M.J.; Michalski L.A.; Turci S.M.; Guillette R.A.; Jue D.L.; Johnson M.H.; Moo-Penn W.F.;
Biochemistry 29:173-178(1990)
Cited for: VARIANT ATTLEBORO PRO-139;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.