Variant position: 140 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAVHASLDKFLASVSTVLTS KYR
Gorilla PAVHASLDKFLASVSTVLTS KYR
Rhesus macaque PAVHASLDKFLASVSTVLTS KYR
Chimpanzee PAVHASLDKFLASVSTVLTS KYR
Mouse PAVHASLDKFLASVSTVLTS KYR
Rat PAMHASLDKFLASVSTVLTS KYR
Pig PSVHASLDKFLANVSTVLTS KYR
Bovine PAVHASLDKFLANVSTVLTS KYR
Rabbit PAVHASLDKFLANVSTVLTS KYR
Sheep PAVHASLDKFLANVSTVLTS KYR
Cat PAVHASLDKFFSAVSTVLTS KYR
Horse PAVHASLDKFLSSVSTVLTS KYR
Chicken PEVHASLDKFLCAVGTVLTA KYR
Xenopus tropicalis PATHKALDKFLVSVSNVLTS KYR
Zebrafish PEVHVSVDKFFNNLALALSE KYR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Hemoglobin Tokoname [alpha 139 (HC 1) Lys leads to Thr]: a new hemoglobin variant with a slightly increased oxygen affinity.
Harano T.; Harano K.; Shibata S.; Ueda S.; Imai K.; Seki M.;
Cited for: VARIANT TOKONAME THR-140;
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