Variant position: 141 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AVHASLDKFLASVSTVLTSK YR
Gorilla AVHASLDKFLASVSTVLTSK YR
Rhesus macaque AVHASLDKFLASVSTVLTSK YR
Chimpanzee AVHASLDKFLASVSTVLTSK YR
Mouse AVHASLDKFLASVSTVLTSK YR
Rat AMHASLDKFLASVSTVLTSK YR
Pig SVHASLDKFLANVSTVLTSK YR
Bovine AVHASLDKFLANVSTVLTSK YR
Rabbit AVHASLDKFLANVSTVLTSK YR
Sheep AVHASLDKFLANVSTVLTSK YR
Cat AVHASLDKFFSAVSTVLTSK YR
Horse AVHASLDKFLSSVSTVLTSK YR
Chicken EVHASLDKFLCAVGTVLTAK YR
Xenopus tropicalis ATHKALDKFLVSVSNVLTSK YR
Zebrafish EVHVSVDKFFNNLALALSEK YR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Hb Ethiopia or alpha 2(140)(HC2)Tyr----His beta 2.
Webber B.B.; Wilson J.B.; Gu L.-H.; Huisman T.H.J.;
Cited for: PROTEIN SEQUENCE OF 128-142; VARIANT ETHIOPIA HIS-141;
Hemoglobin Rouen (alpha-140 (HC2) Tyr-->His): alteration of the alpha-chain C-terminal region and moderate increase in oxygen affinity.
Wajcman H.; Kister J.; Marden M.; Lahary A.; Monconduit M.; Galacteros F.;
Biochim. Biophys. Acta 1180:53-57(1992)
Cited for: VARIANT ROUEN/ETHIOPIA HIS-141;
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