Variant position: 142 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VHASLDKFLASVSTVLTSKY R
Gorilla VHASLDKFLASVSTVLTSKY R
Rhesus macaque VHASLDKFLASVSTVLTSKY R
Chimpanzee VHASLDKFLASVSTVLTSKY R
Mouse VHASLDKFLASVSTVLTSKY R
Rat MHASLDKFLASVSTVLTSKY R
Pig VHASLDKFLANVSTVLTSKY R
Bovine VHASLDKFLANVSTVLTSKY R
Rabbit VHASLDKFLANVSTVLTSKY R
Sheep VHASLDKFLANVSTVLTSKY R
Cat VHASLDKFFSAVSTVLTSKY R
Horse VHASLDKFLSSVSTVLTSKY R
Chicken VHASLDKFLCAVGTVLTAKY R
Xenopus tropicalis THKALDKFLVSVSNVLTSKY R
Zebrafish VHVSVDKFFNNLALALSEKY R
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
125 – 125 Phosphoserine
132 – 132 Phosphoserine
135 – 135 Phosphothreonine
138 – 138 Phosphothreonine
139 – 139 Phosphoserine
Hemoglobin Legnano (alpha 2 141 (HC3) Arg leads to Leu beta2) a new high oxygen affinity variant. Functional and structural studies.
Giuliani A.; Maffi D.; Cappabianca M.P.; Tentori L.;
J. Biochem. 88:1233-1237(1980)
Cited for: VARIANT LEGNANO LEU-142;
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